Cell type atlas - ISG15 - The Human Protein Atlas

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ISG15

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ISG15
Gene descriptionⁱ Full gene name according to HGNC.	ISG15 ubiquitin-like modifier
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts, Smooth muscle cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts, Smooth muscle cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	41 NX
Colon	172 NX
Kidney	40 NX
Liver	28 NX

Basal glandular cells	41 NX
Prostate	41 NX

Basal keratinocytes	40 NX
Skin	40 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	26 NX
Lung	26 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	13 NX
Placenta	13 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	130 NX
Pancreas	129 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	180 NX
Placenta	281 NX
Heart muscle	245 NX
Prostate	225 NX
Eye	206 NX
Testis	158 NX
Skin	156 NX
Pancreas	122 NX
Lung	58 NX
Liver	20 NX

Enterocytes	254 NX
Small intestine	417 NX
Colon	159 NX
Rectum	139 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	242 NX
Pancreas	242 NX

Extravillous trophoblasts	428 NX
Placenta	428 NX

Fibroblasts	86 NX
Skin	102 NX
Prostate	98 NX
Heart muscle	86 NX
Placenta	78 NX
Lung	27 NX

Glandular cells	42 NX
Prostate	42 NX

Granulocytes	60 NX
Colon	74 NX
Lung	47 NX

Hepatocytes	52 NX
Liver	52 NX

Hofbauer cells	239 NX
Placenta	239 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	34 NX
Colon	51 NX
Rectum	16 NX

Ito cells	75 NX
Liver	75 NX

Kupffer cells	63 NX
Liver	63 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	163 NX
Prostate	342 NX
Kidney	320 NX
Skin	185 NX
Lung	163 NX
Testis	95 NX
Pancreas	77 NX

Melanocytes	84 NX
Skin	84 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	58 NX
Pancreas	58 NX

Mucus-secreting cells	87 NX
Small intestine	188 NX
Colon	94 NX
Rectum	7 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	136 NX
Pancreas	136 NX

Paneth cells	228 NX
Colon	803 NX
Small intestine	228 NX
Rectum	42 NX

Peritubular cells	39 NX
Testis	39 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	97 NX
Testis	97 NX

Smooth muscle cells	304 NX
Skin	366 NX
Prostate	306 NX
Heart muscle	148 NX
Pancreas	130 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	32 NX
Skin	32 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	94 NX
Skin	352 NX
Colon	289 NX
Prostate	187 NX
Kidney	166 NX
Lung	94 NX
Liver	76 NX

Undifferentiated cells	16 NX
Colon	43 NX
Small intestine	37 NX
Rectum	3 NX

Urothelial cells	47 NX
Prostate	47 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.