Cell type atlas - USP7 - The Human Protein Atlas

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USP7

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP7
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	46 NX
Lung	46 NX

B-cells	23 NX
Colon	33 NX
Liver	29 NX
Kidney	5 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	41 NX
Skin	41 NX

Bipolar cells	47 NX
Eye	47 NX

Cardiomyocytes	62 NX
Heart muscle	62 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	47 NX
Lung	47 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	18 NX
Placenta	18 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	217 NX
Testis	217 NX

Endothelial cells	26 NX
Heart muscle	63 NX
Liver	47 NX
Prostate	39 NX
Skin	27 NX
Placenta	26 NX
Testis	26 NX
Eye	22 NX
Lung	15 NX
Pancreas	14 NX

Enterocytes	30 NX
Rectum	42 NX
Colon	33 NX
Small intestine	28 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	28 NX
Pancreas	28 NX

Extravillous trophoblasts	13 NX
Placenta	13 NX

Fibroblasts	24 NX
Heart muscle	62 NX
Lung	46 NX
Skin	25 NX
Prostate	23 NX
Placenta	20 NX

Glandular cells	27 NX
Prostate	27 NX

Granulocytes	26 NX
Lung	33 NX
Colon	18 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	18 NX
Placenta	18 NX

Horizontal cells	41 NX
Eye	41 NX

Intestinal endocrine cells	41 NX
Rectum	61 NX
Colon	20 NX

Ito cells	25 NX
Liver	25 NX

Kupffer cells	28 NX
Liver	28 NX

Late spermatids	84 NX
Testis	84 NX

Leydig cells	24 NX
Testis	24 NX

Macrophages	29 NX
Lung	41 NX
Prostate	32 NX
Testis	28 NX
Skin	24 NX
Kidney	21 NX
Pancreas	16 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	16 NX
Pancreas	16 NX

Mucus-secreting cells	47 NX
Rectum	52 NX
Small intestine	42 NX
Colon	35 NX

Muller glia cells	25 NX
Eye	25 NX

Pancreatic endocrine cells	28 NX
Pancreas	28 NX

Paneth cells	29 NX
Rectum	52 NX
Colon	29 NX
Small intestine	25 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	12 NX
Kidney	12 NX

Rod photoreceptor cells	42 NX
Eye	42 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	29 NX
Heart muscle	94 NX
Prostate	29 NX
Skin	22 NX
Pancreas	19 NX

Spermatocytes	30 NX
Testis	30 NX

Spermatogonia	32 NX
Testis	32 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	18 NX
Placenta	18 NX

T-cells	27 NX
Lung	58 NX
Prostate	31 NX
Liver	27 NX
Colon	25 NX
Skin	21 NX
Kidney	14 NX

Undifferentiated cells	47 NX
Rectum	52 NX
Small intestine	41 NX
Colon	33 NX

Urothelial cells	33 NX
Prostate	33 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.