Cell type atlas - TMEM222 - The Human Protein Atlas

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TMEM222

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM222
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 222
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	16 NX
Lung	16 NX

B-cells	16 NX
Kidney	40 NX
Liver	16 NX
Colon	12 NX

Basal glandular cells	12 NX
Prostate	12 NX

Basal keratinocytes	10 NX
Skin	10 NX

Bipolar cells	40 NX
Eye	40 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	5 NX
Lung	5 NX

Club cells	6 NX
Lung	6 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	26 NX
Placenta	26 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	33 NX
Pancreas	33 NX

Early spermatids	20 NX
Testis	20 NX

Endothelial cells	15 NX
Pancreas	54 NX
Placenta	21 NX
Eye	20 NX
Skin	18 NX
Liver	16 NX
Testis	15 NX
Lung	12 NX
Prostate	10 NX
Heart muscle	8 NX

Enterocytes	22 NX
Colon	28 NX
Small intestine	23 NX
Rectum	17 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	35 NX
Pancreas	35 NX

Extravillous trophoblasts	29 NX
Placenta	29 NX

Fibroblasts	24 NX
Skin	27 NX
Placenta	24 NX
Prostate	17 NX
Lung	4 NX
Heart muscle	4 NX

Glandular cells	16 NX
Prostate	16 NX

Granulocytes	16 NX
Lung	23 NX
Colon	9 NX

Hepatocytes	11 NX
Liver	11 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	41 NX
Eye	41 NX

Intestinal endocrine cells	29 NX
Colon	34 NX
Rectum	23 NX

Ito cells	9 NX
Liver	9 NX

Kupffer cells	9 NX
Liver	9 NX

Late spermatids	61 NX
Testis	61 NX

Leydig cells	19 NX
Testis	19 NX

Macrophages	11 NX
Testis	19 NX
Pancreas	19 NX
Skin	15 NX
Kidney	12 NX
Lung	7 NX
Prostate	7 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	30 NX
Pancreas	30 NX

Mucus-secreting cells	17 NX
Colon	23 NX
Small intestine	18 NX
Rectum	15 NX

Muller glia cells	53 NX
Eye	53 NX

Pancreatic endocrine cells	36 NX
Pancreas	36 NX

Paneth cells	18 NX
Colon	29 NX
Small intestine	18 NX
Rectum	15 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	15 NX
Pancreas	49 NX
Skin	16 NX
Prostate	13 NX
Heart muscle	8 NX

Spermatocytes	19 NX
Testis	19 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	22 NX
Liver	28 NX
Colon	24 NX
Kidney	22 NX
Skin	16 NX
Lung	10 NX
Prostate	4 NX

Undifferentiated cells	19 NX
Colon	20 NX
Small intestine	19 NX
Rectum	15 NX

Urothelial cells	10 NX
Prostate	10 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.