Cell type atlas - IRS2 - The Human Protein Atlas

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IRS2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IRS2
Gene descriptionⁱ Full gene name according to HGNC.	Insulin receptor substrate 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTERT-HME1, LHCN-M2, SH-SY5Y, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	14 NX
Colon	54 NX
Kidney	13 NX
Liver	10 NX

Basal glandular cells	48 NX
Prostate	48 NX

Basal keratinocytes	101 NX
Skin	101 NX

Bipolar cells	25 NX
Eye	25 NX

Cardiomyocytes	56 NX
Heart muscle	56 NX

Cholangiocytes	71 NX
Liver	71 NX

Ciliated cells	20 NX
Lung	20 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	30 NX
Kidney	30 NX

Cone photoreceptor cells	108 NX
Eye	108 NX

Cytotrophoblasts	18 NX
Placenta	18 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	32 NX
Testis	32 NX

Endothelial cells	11 NX
Eye	47 NX
Skin	16 NX
Prostate	15 NX
Heart muscle	14 NX
Liver	7 NX
Lung	6 NX
Testis	4 NX
Placenta	3 NX
Pancreas	0 NX

Enterocytes	53 NX
Rectum	75 NX
Small intestine	55 NX
Colon	53 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	3 NX
Pancreas	3 NX

Extravillous trophoblasts	8 NX
Placenta	8 NX

Fibroblasts	42 NX
Prostate	105 NX
Heart muscle	53 NX
Skin	47 NX
Lung	23 NX
Placenta	10 NX

Glandular cells	76 NX
Prostate	76 NX

Granulocytes	24 NX
Lung	30 NX
Colon	18 NX

Hepatocytes	104 NX
Liver	104 NX

Hofbauer cells	21 NX
Placenta	21 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	118 NX
Colon	139 NX
Rectum	96 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	115 NX
Liver	115 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	52 NX
Testis	149 NX
Prostate	89 NX
Lung	86 NX
Kidney	39 NX
Skin	25 NX
Pancreas	5 NX

Melanocytes	123 NX
Skin	123 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	28 NX
Colon	53 NX
Small intestine	35 NX
Rectum	18 NX

Muller glia cells	38 NX
Eye	38 NX

Pancreatic endocrine cells	21 NX
Pancreas	21 NX

Paneth cells	46 NX
Colon	46 NX
Small intestine	46 NX
Rectum	29 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	28 NX
Eye	28 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	34 NX
Prostate	67 NX
Skin	41 NX
Heart muscle	19 NX
Pancreas	4 NX

Spermatocytes	19 NX
Testis	19 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	110 NX
Skin	110 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	25 NX
Prostate	70 NX
Colon	68 NX
Skin	28 NX
Lung	27 NX
Liver	16 NX
Kidney	8 NX

Undifferentiated cells	31 NX
Colon	47 NX
Small intestine	31 NX
Rectum	30 NX

Urothelial cells	21 NX
Prostate	21 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.