Cell type atlas - IFITM1 - The Human Protein Atlas

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IFITM1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IFITM1
Gene descriptionⁱ Full gene name according to HGNC.	Interferon induced transmembrane protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-cells, Leydig cells, Sertoli cells, Club cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (NK-cell, memory CD4 T-cell, naive CD4 T-cell, naive CD8 T-cell, memory CD8 T-cell, gdT-cell, neutrophil, MAIT T-cell, T-reg, eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (T-cells, Leydig cells, Sertoli cells, Club cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	97 NX
Lung	97 NX

B-cells	13 NX
Kidney	22 NX
Colon	13 NX
Liver	6 NX

Basal glandular cells	10 NX
Prostate	10 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	0 NX
Liver	0 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	188 NX
Lung	188 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	1 NX
Pancreas	1 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	147 NX
Testis	585 NX
Skin	344 NX
Heart muscle	207 NX
Liver	148 NX
Placenta	147 NX
Lung	134 NX
Prostate	53 NX
Eye	26 NX
Pancreas	7 NX

Enterocytes	12 NX
Colon	13 NX
Small intestine	13 NX
Rectum	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	1 NX
Pancreas	1 NX

Extravillous trophoblasts	25 NX
Placenta	25 NX

Fibroblasts	132 NX
Lung	234 NX
Skin	141 NX
Placenta	76 NX
Heart muscle	76 NX
Prostate	33 NX

Glandular cells	2 NX
Prostate	2 NX

Granulocytes	17 NX
Lung	35 NX
Colon	0 NX

Hepatocytes	18 NX
Liver	18 NX

Hofbauer cells	9 NX
Placenta	9 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	1 NX
Rectum	2 NX
Colon	0 NX

Ito cells	130 NX
Liver	130 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	279 NX
Testis	279 NX

Macrophages	22 NX
Lung	48 NX
Kidney	45 NX
Testis	28 NX
Skin	22 NX
Pancreas	0 NX
Prostate	0 NX

Melanocytes	74 NX
Skin	74 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	14 NX
Small intestine	30 NX
Rectum	13 NX
Colon	6 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	1 NX
Pancreas	1 NX

Paneth cells	10 NX
Colon	23 NX
Rectum	10 NX
Small intestine	7 NX

Peritubular cells	117 NX
Testis	117 NX

Proximal tubular cells	0 NX
Kidney	0 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	272 NX
Testis	272 NX

Smooth muscle cells	96 NX
Skin	407 NX
Heart muscle	96 NX
Prostate	22 NX
Pancreas	16 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	13 NX
Skin	13 NX

Syncytiotrophoblasts	3 NX
Placenta	3 NX

T-cells	358 NX
Lung	696 NX
Skin	398 NX
Liver	376 NX
Kidney	358 NX
Colon	80 NX
Prostate	18 NX

Undifferentiated cells	24 NX
Small intestine	43 NX
Rectum	19 NX
Colon	18 NX

Urothelial cells	4 NX
Prostate	4 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.