Cell type atlas - DRG1 - The Human Protein Atlas

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DRG1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DRG1
Gene descriptionⁱ Full gene name according to HGNC.	Developmentally regulated GTP binding protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Early spermatids, Late spermatids, Spermatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Early spermatids, Late spermatids, Spermatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	31 NX
Kidney	36 NX
Liver	35 NX
Colon	25 NX

Basal glandular cells	36 NX
Prostate	36 NX

Basal keratinocytes	34 NX
Skin	34 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	45 NX
Heart muscle	45 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	110 NX
Placenta	110 NX

Distal tubular cells	55 NX
Kidney	55 NX

Ductal cells	49 NX
Pancreas	49 NX

Early spermatids	643 NX
Testis	643 NX

Endothelial cells	36 NX
Pancreas	79 NX
Placenta	42 NX
Prostate	39 NX
Testis	37 NX
Liver	36 NX
Heart muscle	36 NX
Lung	23 NX
Skin	22 NX
Eye	18 NX

Enterocytes	24 NX
Small intestine	37 NX
Rectum	24 NX
Colon	16 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	40 NX
Pancreas	40 NX

Extravillous trophoblasts	84 NX
Placenta	84 NX

Fibroblasts	28 NX
Placenta	59 NX
Prostate	37 NX
Heart muscle	28 NX
Lung	24 NX
Skin	23 NX

Glandular cells	32 NX
Prostate	32 NX

Granulocytes	33 NX
Colon	46 NX
Lung	21 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	52 NX
Placenta	52 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	11 NX
Rectum	12 NX
Colon	10 NX

Ito cells	32 NX
Liver	32 NX

Kupffer cells	30 NX
Liver	30 NX

Late spermatids	489 NX
Testis	489 NX

Leydig cells	33 NX
Testis	33 NX

Macrophages	24 NX
Testis	36 NX
Kidney	31 NX
Lung	26 NX
Pancreas	26 NX
Skin	19 NX
Prostate	17 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	37 NX
Pancreas	37 NX

Mucus-secreting cells	30 NX
Rectum	34 NX
Small intestine	30 NX
Colon	21 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	40 NX
Pancreas	40 NX

Paneth cells	28 NX
Rectum	31 NX
Small intestine	28 NX
Colon	14 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	47 NX
Kidney	47 NX

Rod photoreceptor cells	15 NX
Eye	15 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	31 NX
Pancreas	73 NX
Prostate	49 NX
Skin	26 NX
Heart muscle	22 NX

Spermatocytes	203 NX
Testis	203 NX

Spermatogonia	83 NX
Testis	83 NX

Suprabasal keratinocytes	28 NX
Skin	28 NX

Syncytiotrophoblasts	98 NX
Placenta	98 NX

T-cells	27 NX
Liver	36 NX
Kidney	27 NX
Colon	27 NX
Skin	23 NX
Lung	22 NX
Prostate	18 NX

Undifferentiated cells	38 NX
Small intestine	44 NX
Rectum	38 NX
Colon	33 NX

Urothelial cells	41 NX
Prostate	41 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.