Cell type atlas - ZFP36L1 - The Human Protein Atlas

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ZFP36L1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZFP36L1
Gene descriptionⁱ Full gene name according to HGNC.	ZFP36 ring finger protein like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	444 NX
Lung	444 NX

Alveolar cells type 2	400 NX
Lung	400 NX

B-cells	182 NX
Colon	285 NX
Kidney	183 NX
Liver	127 NX

Basal glandular cells	691 NX
Prostate	691 NX

Basal keratinocytes	1185 NX
Skin	1185 NX

Bipolar cells	3 NX
Eye	3 NX

Cardiomyocytes	59 NX
Heart muscle	59 NX

Cholangiocytes	293 NX
Liver	293 NX

Ciliated cells	173 NX
Lung	173 NX

Club cells	385 NX
Lung	385 NX

Collecting duct cells	345 NX
Kidney	345 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	377 NX
Placenta	377 NX

Distal tubular cells	71 NX
Kidney	71 NX

Ductal cells	462 NX
Pancreas	462 NX

Early spermatids	77 NX
Testis	77 NX

Endothelial cells	436 NX
Skin	980 NX
Prostate	563 NX
Placenta	478 NX
Eye	443 NX
Testis	436 NX
Heart muscle	250 NX
Lung	228 NX
Liver	137 NX
Pancreas	79 NX

Enterocytes	121 NX
Rectum	154 NX
Small intestine	124 NX
Colon	106 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	492 NX
Pancreas	492 NX

Extravillous trophoblasts	322 NX
Placenta	322 NX

Fibroblasts	716 NX
Skin	1375 NX
Prostate	937 NX
Placenta	524 NX
Lung	365 NX
Heart muscle	235 NX

Glandular cells	520 NX
Prostate	520 NX

Granulocytes	188 NX
Lung	321 NX
Colon	55 NX

Hepatocytes	516 NX
Liver	516 NX

Hofbauer cells	461 NX
Placenta	461 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	20 NX
Rectum	26 NX
Colon	14 NX

Ito cells	322 NX
Liver	322 NX

Kupffer cells	495 NX
Liver	495 NX

Late spermatids	48 NX
Testis	48 NX

Leydig cells	465 NX
Testis	465 NX

Macrophages	761 NX
Testis	1011 NX
Skin	988 NX
Prostate	753 NX
Kidney	504 NX
Lung	424 NX
Pancreas	133 NX

Melanocytes	501 NX
Skin	501 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	474 NX
Pancreas	474 NX

Mucus-secreting cells	198 NX
Colon	243 NX
Rectum	206 NX
Small intestine	136 NX

Muller glia cells	203 NX
Eye	203 NX

Pancreatic endocrine cells	539 NX
Pancreas	539 NX

Paneth cells	98 NX
Rectum	182 NX
Small intestine	98 NX
Colon	95 NX

Peritubular cells	373 NX
Testis	373 NX

Proximal tubular cells	115 NX
Kidney	115 NX

Rod photoreceptor cells	5 NX
Eye	5 NX

Sertoli cells	265 NX
Testis	265 NX

Smooth muscle cells	913 NX
Skin	1122 NX
Prostate	969 NX
Heart muscle	244 NX
Pancreas	161 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	4 NX
Testis	4 NX

Suprabasal keratinocytes	2818 NX
Skin	2818 NX

Syncytiotrophoblasts	752 NX
Placenta	752 NX

T-cells	208 NX
Skin	561 NX
Lung	325 NX
Colon	209 NX
Prostate	205 NX
Liver	205 NX
Kidney	133 NX

Undifferentiated cells	167 NX
Small intestine	206 NX
Rectum	165 NX
Colon	150 NX

Urothelial cells	697 NX
Prostate	697 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.