Cell type atlas - H1FX - The Human Protein Atlas

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H1FX

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	H1FX
Gene descriptionⁱ Full gene name according to HGNC.	H1 histone family member X
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	95 NX
Kidney	276 NX
Liver	93 NX
Colon	19 NX

Basal glandular cells	485 NX
Prostate	485 NX

Basal keratinocytes	90 NX
Skin	90 NX

Bipolar cells	119 NX
Eye	119 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	3 NX
Lung	3 NX

Club cells	3 NX
Lung	3 NX

Collecting duct cells	89 NX
Kidney	89 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	60 NX
Placenta	60 NX

Distal tubular cells	95 NX
Kidney	95 NX

Ductal cells	43 NX
Pancreas	43 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	90 NX
Eye	198 NX
Prostate	141 NX
Skin	115 NX
Testis	113 NX
Liver	90 NX
Placenta	78 NX
Pancreas	68 NX
Heart muscle	41 NX
Lung	15 NX

Enterocytes	34 NX
Rectum	63 NX
Colon	34 NX
Small intestine	24 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	71 NX
Pancreas	71 NX

Extravillous trophoblasts	93 NX
Placenta	93 NX

Fibroblasts	97 NX
Prostate	207 NX
Skin	104 NX
Placenta	71 NX
Heart muscle	18 NX
Lung	8 NX

Glandular cells	174 NX
Prostate	174 NX

Granulocytes	6 NX
Colon	9 NX
Lung	2 NX

Hepatocytes	39 NX
Liver	39 NX

Hofbauer cells	78 NX
Placenta	78 NX

Horizontal cells	138 NX
Eye	138 NX

Intestinal endocrine cells	153 NX
Rectum	187 NX
Colon	119 NX

Ito cells	85 NX
Liver	85 NX

Kupffer cells	94 NX
Liver	93 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	92 NX
Testis	92 NX

Macrophages	76 NX
Kidney	211 NX
Prostate	176 NX
Testis	91 NX
Skin	84 NX
Pancreas	61 NX
Lung	9 NX

Melanocytes	118 NX
Skin	118 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	86 NX
Small intestine	93 NX
Rectum	88 NX
Colon	78 NX

Muller glia cells	210 NX
Eye	210 NX

Pancreatic endocrine cells	59 NX
Pancreas	59 NX

Paneth cells	49 NX
Rectum	71 NX
Colon	49 NX
Small intestine	35 NX

Peritubular cells	49 NX
Testis	49 NX

Proximal tubular cells	25 NX
Kidney	25 NX

Rod photoreceptor cells	84 NX
Eye	84 NX

Sertoli cells	123 NX
Testis	123 NX

Smooth muscle cells	82 NX
Prostate	259 NX
Skin	85 NX
Pancreas	61 NX
Heart muscle	29 NX

Spermatocytes	13 NX
Testis	13 NX

Spermatogonia	37 NX
Testis	37 NX

Suprabasal keratinocytes	96 NX
Skin	96 NX

Syncytiotrophoblasts	57 NX
Placenta	57 NX

T-cells	73 NX
Prostate	519 NX
Kidney	299 NX
Liver	86 NX
Colon	73 NX
Skin	56 NX
Lung	12 NX

Undifferentiated cells	53 NX
Small intestine	72 NX
Rectum	58 NX
Colon	41 NX

Urothelial cells	312 NX
Prostate	312 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.