Cell type atlas - NDUFA12 - The Human Protein Atlas

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NDUFA12

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA12
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Cardiomyocytes, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Cardiomyocytes, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	69 NX
Lung	69 NX

Alveolar cells type 2	59 NX
Lung	59 NX

B-cells	80 NX
Liver	100 NX
Kidney	94 NX
Colon	66 NX

Basal glandular cells	121 NX
Prostate	121 NX

Basal keratinocytes	97 NX
Skin	97 NX

Bipolar cells	66 NX
Eye	66 NX

Cardiomyocytes	2083 NX
Heart muscle	2083 NX

Cholangiocytes	161 NX
Liver	161 NX

Ciliated cells	78 NX
Lung	78 NX

Club cells	46 NX
Lung	46 NX

Collecting duct cells	103 NX
Kidney	103 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	216 NX
Placenta	216 NX

Distal tubular cells	526 NX
Kidney	526 NX

Ductal cells	141 NX
Pancreas	141 NX

Early spermatids	193 NX
Testis	193 NX

Endothelial cells	158 NX
Heart muscle	581 NX
Pancreas	276 NX
Placenta	267 NX
Testis	216 NX
Eye	158 NX
Prostate	145 NX
Skin	117 NX
Lung	102 NX
Liver	94 NX

Enterocytes	177 NX
Small intestine	199 NX
Colon	172 NX
Rectum	159 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	143 NX
Pancreas	143 NX

Extravillous trophoblasts	215 NX
Placenta	215 NX

Fibroblasts	94 NX
Heart muscle	777 NX
Placenta	182 NX
Skin	88 NX
Lung	56 NX
Prostate	43 NX

Glandular cells	121 NX
Prostate	121 NX

Granulocytes	57 NX
Lung	58 NX
Colon	55 NX

Hepatocytes	123 NX
Liver	123 NX

Hofbauer cells	169 NX
Placenta	169 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	82 NX
Rectum	96 NX
Colon	68 NX

Ito cells	99 NX
Liver	99 NX

Kupffer cells	96 NX
Liver	96 NX

Late spermatids	71 NX
Testis	71 NX

Leydig cells	90 NX
Testis	90 NX

Macrophages	126 NX
Pancreas	190 NX
Kidney	179 NX
Skin	174 NX
Testis	114 NX
Prostate	96 NX
Lung	81 NX

Melanocytes	152 NX
Skin	152 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	218 NX
Pancreas	218 NX

Mucus-secreting cells	147 NX
Colon	185 NX
Rectum	154 NX
Small intestine	119 NX

Muller glia cells	79 NX
Eye	79 NX

Pancreatic endocrine cells	170 NX
Pancreas	170 NX

Paneth cells	189 NX
Colon	250 NX
Rectum	189 NX
Small intestine	179 NX

Peritubular cells	126 NX
Testis	126 NX

Proximal tubular cells	243 NX
Kidney	243 NX

Rod photoreceptor cells	113 NX
Eye	113 NX

Sertoli cells	104 NX
Testis	104 NX

Smooth muscle cells	150 NX
Heart muscle	615 NX
Pancreas	199 NX
Skin	140 NX
Prostate	120 NX

Spermatocytes	131 NX
Testis	131 NX

Spermatogonia	119 NX
Testis	119 NX

Suprabasal keratinocytes	112 NX
Skin	112 NX

Syncytiotrophoblasts	175 NX
Placenta	175 NX

T-cells	97 NX
Skin	188 NX
Kidney	186 NX
Colon	107 NX
Lung	101 NX
Liver	86 NX
Prostate	70 NX

Undifferentiated cells	189 NX
Colon	233 NX
Rectum	196 NX
Small intestine	174 NX

Urothelial cells	183 NX
Prostate	183 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.