Cell type atlas - TACSTD2 - The Human Protein Atlas

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TACSTD2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TACSTD2
Gene descriptionⁱ Full gene name according to HGNC.	Tumor associated calcium signal transducer 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Basal glandular cells, Glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Basal glandular cells, Glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	322 NX
Lung	322 NX

Alveolar cells type 2	110 NX
Lung	110 NX

B-cells	1 NX
Kidney	5 NX
Colon	2 NX
Liver	1 NX

Basal glandular cells	5162 NX
Prostate	5162 NX

Basal keratinocytes	1324 NX
Skin	1324 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	288 NX
Liver	288 NX

Ciliated cells	277 NX
Lung	277 NX

Club cells	313 NX
Lung	313 NX

Collecting duct cells	1213 NX
Kidney	1213 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	75 NX
Placenta	75 NX

Distal tubular cells	37 NX
Kidney	37 NX

Ductal cells	1546 NX
Pancreas	1546 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	14 NX
Prostate	320 NX
Skin	127 NX
Pancreas	32 NX
Lung	18 NX
Placenta	14 NX
Liver	5 NX
Testis	1 NX
Heart muscle	1 NX
Eye	0 NX

Enterocytes	0 NX
Colon	3 NX
Rectum	0 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	1123 NX
Pancreas	1123 NX

Extravillous trophoblasts	5 NX
Placenta	5 NX

Fibroblasts	23 NX
Prostate	224 NX
Skin	60 NX
Lung	19 NX
Placenta	8 NX
Heart muscle	0 NX

Glandular cells	2977 NX
Prostate	2977 NX

Granulocytes	8 NX
Lung	16 NX
Colon	0 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	8 NX
Placenta	8 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	0 NX
Colon	0 NX
Rectum	0 NX

Ito cells	1 NX
Liver	1 NX

Kupffer cells	0 NX
Liver	0 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	0 NX
Testis	0 NX

Macrophages	32 NX
Prostate	266 NX
Skin	133 NX
Pancreas	35 NX
Lung	19 NX
Kidney	11 NX
Testis	3 NX

Melanocytes	108 NX
Skin	108 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	54 NX
Pancreas	54 NX

Mucus-secreting cells	3 NX
Colon	18 NX
Rectum	3 NX
Small intestine	1 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	1294 NX
Pancreas	1294 NX

Paneth cells	4 NX
Colon	6 NX
Rectum	4 NX
Small intestine	0 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	47 NX
Prostate	435 NX
Pancreas	58 NX
Skin	39 NX
Heart muscle	0 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	1339 NX
Skin	1339 NX

Syncytiotrophoblasts	66 NX
Placenta	66 NX

T-cells	0 NX
Prostate	344 NX
Skin	45 NX
Lung	20 NX
Kidney	1 NX
Liver	0 NX
Colon	0 NX

Undifferentiated cells	1 NX
Rectum	2 NX
Small intestine	1 NX
Colon	0 NX

Urothelial cells	7435 NX
Prostate	7435 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.