Cell type atlas - ACTG1 - The Human Protein Atlas

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ACTG1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACTG1
Gene descriptionⁱ Full gene name according to HGNC.	Actin gamma 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	905 NX
Lung	905 NX

Alveolar cells type 2	511 NX
Lung	511 NX

B-cells	891 NX
Liver	1346 NX
Kidney	900 NX
Colon	718 NX

Basal glandular cells	7658 NX
Prostate	7658 NX

Basal keratinocytes	4687 NX
Skin	4687 NX

Bipolar cells	428 NX
Eye	428 NX

Cardiomyocytes	211 NX
Heart muscle	211 NX

Cholangiocytes	810 NX
Liver	810 NX

Ciliated cells	750 NX
Lung	750 NX

Club cells	818 NX
Lung	818 NX

Collecting duct cells	1082 NX
Kidney	1082 NX

Cone photoreceptor cells	230 NX
Eye	230 NX

Cytotrophoblasts	1816 NX
Placenta	1816 NX

Distal tubular cells	897 NX
Kidney	897 NX

Ductal cells	4218 NX
Pancreas	4218 NX

Early spermatids	215 NX
Testis	215 NX

Endothelial cells	967 NX
Pancreas	2786 NX
Placenta	2189 NX
Prostate	1604 NX
Skin	1435 NX
Testis	1427 NX
Eye	930 NX
Liver	740 NX
Lung	639 NX
Heart muscle	474 NX

Enterocytes	1766 NX
Rectum	2639 NX
Colon	1766 NX
Small intestine	1336 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	7168 NX
Pancreas	7168 NX

Extravillous trophoblasts	3344 NX
Placenta	3344 NX

Fibroblasts	1493 NX
Placenta	2358 NX
Skin	1504 NX
Prostate	1269 NX
Lung	1139 NX
Heart muscle	412 NX

Glandular cells	3297 NX
Prostate	3297 NX

Granulocytes	567 NX
Lung	674 NX
Colon	459 NX

Hepatocytes	422 NX
Liver	422 NX

Hofbauer cells	2859 NX
Placenta	2859 NX

Horizontal cells	253 NX
Eye	253 NX

Intestinal endocrine cells	1841 NX
Rectum	2387 NX
Colon	1295 NX

Ito cells	1007 NX
Liver	1007 NX

Kupffer cells	1380 NX
Liver	1380 NX

Late spermatids	206 NX
Testis	206 NX

Leydig cells	1591 NX
Testis	1591 NX

Macrophages	1423 NX
Pancreas	2721 NX
Prostate	1610 NX
Skin	1518 NX
Testis	1465 NX
Kidney	1360 NX
Lung	1007 NX

Melanocytes	1326 NX
Skin	1326 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5071 NX
Pancreas	5071 NX

Mucus-secreting cells	2073 NX
Rectum	2271 NX
Colon	1929 NX
Small intestine	1597 NX

Muller glia cells	2735 NX
Eye	2735 NX

Pancreatic endocrine cells	5698 NX
Pancreas	5697 NX

Paneth cells	2397 NX
Colon	2732 NX
Rectum	2397 NX
Small intestine	1406 NX

Peritubular cells	1282 NX
Testis	1282 NX

Proximal tubular cells	371 NX
Kidney	371 NX

Rod photoreceptor cells	439 NX
Eye	439 NX

Sertoli cells	1339 NX
Testis	1339 NX

Smooth muscle cells	1183 NX
Pancreas	5193 NX
Prostate	1602 NX
Skin	1097 NX
Heart muscle	520 NX

Spermatocytes	772 NX
Testis	772 NX

Spermatogonia	1035 NX
Testis	1035 NX

Suprabasal keratinocytes	4696 NX
Skin	4696 NX

Syncytiotrophoblasts	2364 NX
Placenta	2364 NX

T-cells	1581 NX
Skin	1788 NX
Liver	1665 NX
Kidney	1581 NX
Prostate	1264 NX
Lung	884 NX
Colon	817 NX

Undifferentiated cells	2117 NX
Small intestine	2184 NX
Rectum	2161 NX
Colon	1390 NX

Urothelial cells	4780 NX
Prostate	4780 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.