Cell type atlas - TBK1 - The Human Protein Atlas

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TBK1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TBK1
Gene descriptionⁱ Full gene name according to HGNC.	TANK binding kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	16 NX
Lung	16 NX

B-cells	15 NX
Kidney	18 NX
Colon	15 NX
Liver	14 NX

Basal glandular cells	24 NX
Prostate	24 NX

Basal keratinocytes	10 NX
Skin	10 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	19 NX
Lung	19 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	25 NX
Placenta	25 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	17 NX
Pancreas	17 NX

Early spermatids	25 NX
Testis	25 NX

Endothelial cells	24 NX
Prostate	59 NX
Pancreas	36 NX
Testis	30 NX
Lung	29 NX
Eye	28 NX
Heart muscle	22 NX
Liver	18 NX
Skin	17 NX
Placenta	12 NX

Enterocytes	11 NX
Rectum	12 NX
Colon	12 NX
Small intestine	11 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	24 NX
Placenta	24 NX

Fibroblasts	14 NX
Prostate	36 NX
Lung	29 NX
Skin	15 NX
Heart muscle	14 NX
Placenta	13 NX

Glandular cells	35 NX
Prostate	35 NX

Granulocytes	42 NX
Lung	47 NX
Colon	37 NX

Hepatocytes	14 NX
Liver	14 NX

Hofbauer cells	18 NX
Placenta	18 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	17 NX
Colon	24 NX
Rectum	9 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	20 NX
Testis	20 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	26 NX
Prostate	52 NX
Lung	32 NX
Pancreas	23 NX
Skin	20 NX
Kidney	20 NX
Testis	15 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	8 NX
Small intestine	16 NX
Rectum	8 NX
Colon	6 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	14 NX
Pancreas	14 NX

Paneth cells	10 NX
Small intestine	14 NX
Rectum	10 NX
Colon	6 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	12 NX
Kidney	12 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	18 NX
Prostate	27 NX
Skin	21 NX
Pancreas	18 NX
Heart muscle	10 NX

Spermatocytes	50 NX
Testis	50 NX

Spermatogonia	13 NX
Testis	13 NX

Suprabasal keratinocytes	13 NX
Skin	13 NX

Syncytiotrophoblasts	78 NX
Placenta	78 NX

T-cells	26 NX
Prostate	52 NX
Lung	35 NX
Kidney	27 NX
Colon	26 NX
Skin	23 NX
Liver	18 NX

Undifferentiated cells	9 NX
Small intestine	10 NX
Colon	10 NX
Rectum	9 NX

Urothelial cells	32 NX
Prostate	32 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.