Cell type atlas - NDUFB1 - The Human Protein Atlas

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NDUFB1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFB1
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit B1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	155 NX
Lung	155 NX

Alveolar cells type 2	246 NX
Lung	246 NX

B-cells	237 NX
Liver	480 NX
Kidney	223 NX
Colon	108 NX

Basal glandular cells	88 NX
Prostate	88 NX

Basal keratinocytes	114 NX
Skin	114 NX

Bipolar cells	73 NX
Eye	73 NX

Cardiomyocytes	2033 NX
Heart muscle	2033 NX

Cholangiocytes	566 NX
Liver	566 NX

Ciliated cells	282 NX
Lung	282 NX

Club cells	179 NX
Lung	179 NX

Collecting duct cells	370 NX
Kidney	370 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	225 NX
Placenta	225 NX

Distal tubular cells	988 NX
Kidney	988 NX

Ductal cells	197 NX
Pancreas	197 NX

Early spermatids	99 NX
Testis	99 NX

Endothelial cells	145 NX
Liver	452 NX
Heart muscle	353 NX
Testis	282 NX
Placenta	223 NX
Eye	145 NX
Skin	129 NX
Pancreas	129 NX
Lung	120 NX
Prostate	53 NX

Enterocytes	655 NX
Small intestine	685 NX
Colon	571 NX
Rectum	527 NX

Erythroid cells	280 NX
Liver	280 NX

Exocrine glandular cells	372 NX
Pancreas	372 NX

Extravillous trophoblasts	86 NX
Placenta	86 NX

Fibroblasts	165 NX
Heart muscle	672 NX
Placenta	199 NX
Lung	154 NX
Skin	143 NX
Prostate	43 NX

Glandular cells	117 NX
Prostate	117 NX

Granulocytes	207 NX
Lung	258 NX
Colon	156 NX

Hepatocytes	1436 NX
Liver	1436 NX

Hofbauer cells	359 NX
Placenta	359 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	305 NX
Rectum	386 NX
Colon	224 NX

Ito cells	427 NX
Liver	427 NX

Kupffer cells	708 NX
Liver	708 NX

Late spermatids	29 NX
Testis	29 NX

Leydig cells	243 NX
Testis	243 NX

Macrophages	282 NX
Kidney	650 NX
Pancreas	445 NX
Testis	321 NX
Lung	299 NX
Skin	170 NX
Prostate	96 NX

Melanocytes	316 NX
Skin	316 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	297 NX
Pancreas	297 NX

Mucus-secreting cells	434 NX
Colon	525 NX
Small intestine	428 NX
Rectum	402 NX

Muller glia cells	109 NX
Eye	109 NX

Pancreatic endocrine cells	269 NX
Pancreas	269 NX

Paneth cells	512 NX
Colon	806 NX
Small intestine	512 NX
Rectum	376 NX

Peritubular cells	227 NX
Testis	227 NX

Proximal tubular cells	865 NX
Kidney	865 NX

Rod photoreceptor cells	131 NX
Eye	131 NX

Sertoli cells	220 NX
Testis	220 NX

Smooth muscle cells	185 NX
Heart muscle	424 NX
Pancreas	222 NX
Skin	174 NX
Prostate	82 NX

Spermatocytes	134 NX
Testis	134 NX

Spermatogonia	145 NX
Testis	145 NX

Suprabasal keratinocytes	154 NX
Skin	154 NX

Syncytiotrophoblasts	172 NX
Placenta	172 NX

T-cells	204 NX
Kidney	268 NX
Liver	230 NX
Lung	204 NX
Skin	152 NX
Colon	133 NX
Prostate	83 NX

Undifferentiated cells	467 NX
Small intestine	487 NX
Rectum	467 NX
Colon	372 NX

Urothelial cells	90 NX
Prostate	90 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.