Cell type atlas - GAS6 - The Human Protein Atlas

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GAS6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GAS6
Gene descriptionⁱ Full gene name according to HGNC.	Growth arrest specific 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Horizontal cells, Sertoli cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ, BJ hTERT+, HSkMC, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Horizontal cells, Sertoli cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	185 NX
Lung	185 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	12 NX
Liver	59 NX
Kidney	9 NX
Colon	9 NX

Basal glandular cells	78 NX
Prostate	78 NX

Basal keratinocytes	75 NX
Skin	75 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	76 NX
Heart muscle	76 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	30 NX
Kidney	30 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	2 NX
Placenta	2 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	59 NX
Heart muscle	99 NX
Eye	87 NX
Lung	76 NX
Prostate	59 NX
Skin	57 NX
Liver	54 NX
Testis	53 NX
Pancreas	18 NX
Placenta	6 NX

Enterocytes	72 NX
Rectum	92 NX
Colon	86 NX
Small intestine	69 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	6 NX
Pancreas	6 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	59 NX
Prostate	111 NX
Skin	108 NX
Heart muscle	73 NX
Lung	36 NX
Placenta	20 NX

Glandular cells	13 NX
Prostate	13 NX

Granulocytes	8 NX
Colon	9 NX
Lung	7 NX

Hepatocytes	20 NX
Liver	20 NX

Hofbauer cells	77 NX
Placenta	77 NX

Horizontal cells	329 NX
Eye	329 NX

Intestinal endocrine cells	10 NX
Rectum	16 NX
Colon	3 NX

Ito cells	109 NX
Liver	109 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	85 NX
Testis	85 NX

Macrophages	19 NX
Skin	114 NX
Testis	54 NX
Prostate	21 NX
Kidney	16 NX
Pancreas	9 NX
Lung	8 NX

Melanocytes	116 NX
Skin	116 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	12 NX
Pancreas	12 NX

Mucus-secreting cells	58 NX
Rectum	79 NX
Small intestine	56 NX
Colon	36 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	16 NX
Pancreas	16 NX

Paneth cells	32 NX
Rectum	111 NX
Small intestine	32 NX
Colon	17 NX

Peritubular cells	56 NX
Testis	56 NX

Proximal tubular cells	0 NX
Kidney	0 NX

Rod photoreceptor cells	9 NX
Eye	9 NX

Sertoli cells	317 NX
Testis	317 NX

Smooth muscle cells	125 NX
Heart muscle	130 NX
Prostate	125 NX
Skin	112 NX
Pancreas	39 NX

Spermatocytes	4 NX
Testis	4 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	63 NX
Skin	63 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	4 NX
Skin	16 NX
Prostate	9 NX
Lung	4 NX
Kidney	4 NX
Colon	4 NX
Liver	0 NX

Undifferentiated cells	132 NX
Rectum	157 NX
Small intestine	96 NX
Colon	85 NX

Urothelial cells	34 NX
Prostate	34 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.