Cell type atlas - CRIP2 - The Human Protein Atlas

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CRIP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CRIP2
Gene descriptionⁱ Full gene name according to HGNC.	Cysteine rich protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Endothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-reg, memory CD4 T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, EFO-21, HUVEC TERT2, MCF7, SK-BR-3, T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Endothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	146 NX
Lung	146 NX

Alveolar cells type 2	41 NX
Lung	41 NX

B-cells	7 NX
Liver	18 NX
Kidney	5 NX
Colon	5 NX

Basal glandular cells	66 NX
Prostate	66 NX

Basal keratinocytes	136 NX
Skin	136 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	703 NX
Heart muscle	703 NX

Cholangiocytes	97 NX
Liver	97 NX

Ciliated cells	106 NX
Lung	106 NX

Club cells	132 NX
Lung	132 NX

Collecting duct cells	180 NX
Kidney	180 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	131 NX
Kidney	131 NX

Ductal cells	90 NX
Pancreas	90 NX

Early spermatids	31 NX
Testis	31 NX

Endothelial cells	479 NX
Heart muscle	812 NX
Skin	597 NX
Placenta	523 NX
Liver	479 NX
Testis	440 NX
Pancreas	433 NX
Lung	350 NX
Prostate	300 NX
Eye	281 NX

Enterocytes	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	80 NX
Pancreas	80 NX

Extravillous trophoblasts	15 NX
Placenta	15 NX

Fibroblasts	146 NX
Heart muscle	597 NX
Lung	168 NX
Skin	154 NX
Placenta	31 NX
Prostate	19 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	7 NX
Lung	14 NX
Colon	0 NX

Hepatocytes	27 NX
Liver	27 NX

Hofbauer cells	3 NX
Placenta	3 NX

Horizontal cells	89 NX
Eye	89 NX

Intestinal endocrine cells	24 NX
Rectum	28 NX
Colon	20 NX

Ito cells	230 NX
Liver	230 NX

Kupffer cells	14 NX
Liver	14 NX

Late spermatids	62 NX
Testis	62 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	11 NX
Skin	64 NX
Lung	18 NX
Prostate	11 NX
Kidney	8 NX
Testis	3 NX
Pancreas	2 NX

Melanocytes	149 NX
Skin	149 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3 NX
Pancreas	3 NX

Mucus-secreting cells	0 NX
Colon	1 NX
Rectum	0 NX
Small intestine	0 NX

Muller glia cells	55 NX
Eye	55 NX

Pancreatic endocrine cells	33 NX
Pancreas	33 NX

Paneth cells	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Peritubular cells	14 NX
Testis	14 NX

Proximal tubular cells	10 NX
Kidney	10 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	272 NX
Testis	272 NX

Smooth muscle cells	208 NX
Heart muscle	1194 NX
Skin	247 NX
Prostate	199 NX
Pancreas	122 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	172 NX
Skin	172 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	6 NX
Skin	161 NX
Kidney	36 NX
Lung	25 NX
Liver	6 NX
Prostate	4 NX
Colon	3 NX

Undifferentiated cells	0 NX
Rectum	0 NX
Small intestine	0 NX
Colon	0 NX

Urothelial cells	77 NX
Prostate	77 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.