Cell type atlas - TTC3 - The Human Protein Atlas

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TTC3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TTC3
Gene descriptionⁱ Full gene name according to HGNC.	Tetratricopeptide repeat domain 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	116 NX
Lung	116 NX

Alveolar cells type 2	119 NX
Lung	119 NX

B-cells	110 NX
Colon	200 NX
Liver	101 NX
Kidney	94 NX

Basal glandular cells	81 NX
Prostate	81 NX

Basal keratinocytes	59 NX
Skin	59 NX

Bipolar cells	345 NX
Eye	345 NX

Cardiomyocytes	127 NX
Heart muscle	127 NX

Cholangiocytes	56 NX
Liver	56 NX

Ciliated cells	75 NX
Lung	75 NX

Club cells	101 NX
Lung	101 NX

Collecting duct cells	72 NX
Kidney	72 NX

Cone photoreceptor cells	214 NX
Eye	214 NX

Cytotrophoblasts	40 NX
Placenta	40 NX

Distal tubular cells	141 NX
Kidney	141 NX

Ductal cells	75 NX
Pancreas	75 NX

Early spermatids	160 NX
Testis	160 NX

Endothelial cells	68 NX
Heart muscle	95 NX
Lung	76 NX
Testis	70 NX
Eye	68 NX
Placenta	68 NX
Liver	61 NX
Skin	56 NX
Pancreas	43 NX
Prostate	32 NX

Enterocytes	60 NX
Colon	66 NX
Rectum	61 NX
Small intestine	55 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	66 NX
Pancreas	66 NX

Extravillous trophoblasts	80 NX
Placenta	80 NX

Fibroblasts	133 NX
Skin	152 NX
Lung	148 NX
Placenta	131 NX
Heart muscle	124 NX
Prostate	103 NX

Glandular cells	165 NX
Prostate	165 NX

Granulocytes	62 NX
Lung	70 NX
Colon	55 NX

Hepatocytes	81 NX
Liver	81 NX

Hofbauer cells	56 NX
Placenta	56 NX

Horizontal cells	311 NX
Eye	311 NX

Intestinal endocrine cells	183 NX
Colon	211 NX
Rectum	155 NX

Ito cells	103 NX
Liver	103 NX

Kupffer cells	80 NX
Liver	80 NX

Late spermatids	149 NX
Testis	149 NX

Leydig cells	195 NX
Testis	195 NX

Macrophages	74 NX
Lung	94 NX
Skin	77 NX
Testis	74 NX
Prostate	69 NX
Pancreas	52 NX
Kidney	50 NX

Melanocytes	201 NX
Skin	201 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	61 NX
Pancreas	61 NX

Mucus-secreting cells	134 NX
Colon	186 NX
Rectum	134 NX
Small intestine	99 NX

Muller glia cells	188 NX
Eye	188 NX

Pancreatic endocrine cells	72 NX
Pancreas	72 NX

Paneth cells	84 NX
Rectum	130 NX
Small intestine	84 NX
Colon	49 NX

Peritubular cells	245 NX
Testis	245 NX

Proximal tubular cells	82 NX
Kidney	82 NX

Rod photoreceptor cells	229 NX
Eye	229 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	104 NX
Heart muscle	108 NX
Pancreas	104 NX
Prostate	93 NX
Skin	90 NX

Spermatocytes	264 NX
Testis	264 NX

Spermatogonia	280 NX
Testis	280 NX

Suprabasal keratinocytes	55 NX
Skin	55 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	77 NX
Colon	108 NX
Kidney	89 NX
Prostate	87 NX
Skin	79 NX
Lung	65 NX
Liver	47 NX

Undifferentiated cells	118 NX
Colon	168 NX
Rectum	131 NX
Small intestine	99 NX

Urothelial cells	90 NX
Prostate	90 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.