Cell type atlas - ADI1 - The Human Protein Atlas

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ADI1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADI1
Gene descriptionⁱ Full gene name according to HGNC.	Acireductone dioxygenase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Proximal tubular cells, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	88 NX
Lung	88 NX

B-cells	109 NX
Kidney	156 NX
Liver	109 NX
Colon	57 NX

Basal glandular cells	119 NX
Prostate	119 NX

Basal keratinocytes	68 NX
Skin	68 NX

Bipolar cells	8 NX
Eye	8 NX

Cardiomyocytes	255 NX
Heart muscle	255 NX

Cholangiocytes	285 NX
Liver	285 NX

Ciliated cells	34 NX
Lung	34 NX

Club cells	57 NX
Lung	57 NX

Collecting duct cells	145 NX
Kidney	145 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	343 NX
Placenta	343 NX

Distal tubular cells	753 NX
Kidney	753 NX

Ductal cells	122 NX
Pancreas	122 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	56 NX
Liver	92 NX
Placenta	81 NX
Heart muscle	63 NX
Skin	63 NX
Testis	55 NX
Pancreas	50 NX
Eye	44 NX
Prostate	43 NX
Lung	29 NX

Enterocytes	182 NX
Small intestine	339 NX
Rectum	150 NX
Colon	82 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	77 NX
Pancreas	77 NX

Extravillous trophoblasts	194 NX
Placenta	194 NX

Fibroblasts	105 NX
Heart muscle	176 NX
Placenta	117 NX
Prostate	105 NX
Lung	94 NX
Skin	91 NX

Glandular cells	160 NX
Prostate	160 NX

Granulocytes	41 NX
Lung	44 NX
Colon	37 NX

Hepatocytes	1080 NX
Liver	1080 NX

Hofbauer cells	212 NX
Placenta	212 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	55 NX
Colon	82 NX
Rectum	28 NX

Ito cells	165 NX
Liver	165 NX

Kupffer cells	143 NX
Liver	143 NX

Late spermatids	17 NX
Testis	17 NX

Leydig cells	127 NX
Testis	127 NX

Macrophages	60 NX
Kidney	179 NX
Pancreas	124 NX
Prostate	62 NX
Skin	60 NX
Testis	46 NX
Lung	44 NX

Melanocytes	194 NX
Skin	194 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	117 NX
Pancreas	117 NX

Mucus-secreting cells	123 NX
Colon	144 NX
Small intestine	140 NX
Rectum	114 NX

Muller glia cells	124 NX
Eye	124 NX

Pancreatic endocrine cells	77 NX
Pancreas	77 NX

Paneth cells	181 NX
Small intestine	386 NX
Rectum	181 NX
Colon	179 NX

Peritubular cells	198 NX
Testis	198 NX

Proximal tubular cells	1041 NX
Kidney	1041 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	162 NX
Testis	162 NX

Smooth muscle cells	120 NX
Prostate	158 NX
Skin	122 NX
Heart muscle	120 NX
Pancreas	99 NX

Spermatocytes	5 NX
Testis	5 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	67 NX
Skin	67 NX

Syncytiotrophoblasts	319 NX
Placenta	319 NX

T-cells	55 NX
Kidney	130 NX
Liver	63 NX
Colon	55 NX
Lung	49 NX
Prostate	48 NX
Skin	48 NX

Undifferentiated cells	136 NX
Small intestine	143 NX
Colon	137 NX
Rectum	107 NX

Urothelial cells	118 NX
Prostate	118 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.