Cell type atlas - FAM104B - The Human Protein Atlas

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FAM104B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM104B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 104 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at transcript level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	16 NX
Kidney	18 NX
Colon	13 NX
Liver	12 NX

Basal glandular cells	17 NX
Prostate	17 NX

Basal keratinocytes	14 NX
Skin	14 NX

Bipolar cells	7 NX
Eye	7 NX

Cardiomyocytes	43 NX
Heart muscle	43 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	76 NX
Lung	76 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	38 NX
Kidney	38 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	105 NX
Testis	105 NX

Endothelial cells	16 NX
Placenta	32 NX
Testis	21 NX
Heart muscle	20 NX
Lung	18 NX
Liver	16 NX
Eye	13 NX
Skin	12 NX
Pancreas	11 NX
Prostate	11 NX

Enterocytes	12 NX
Rectum	26 NX
Colon	13 NX
Small intestine	10 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	26 NX
Pancreas	26 NX

Extravillous trophoblasts	43 NX
Placenta	43 NX

Fibroblasts	22 NX
Heart muscle	47 NX
Lung	28 NX
Placenta	23 NX
Skin	18 NX
Prostate	10 NX

Glandular cells	13 NX
Prostate	13 NX

Granulocytes	49 NX
Lung	51 NX
Colon	46 NX

Hepatocytes	20 NX
Liver	20 NX

Hofbauer cells	29 NX
Placenta	29 NX

Horizontal cells	5 NX
Eye	5 NX

Intestinal endocrine cells	18 NX
Rectum	33 NX
Colon	3 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	12 NX
Liver	12 NX

Late spermatids	171 NX
Testis	171 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	13 NX
Kidney	31 NX
Testis	19 NX
Skin	17 NX
Pancreas	12 NX
Lung	10 NX
Prostate	7 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	8 NX
Pancreas	8 NX

Mucus-secreting cells	23 NX
Rectum	28 NX
Small intestine	22 NX
Colon	19 NX

Muller glia cells	18 NX
Eye	18 NX

Pancreatic endocrine cells	18 NX
Pancreas	18 NX

Paneth cells	46 NX
Rectum	52 NX
Small intestine	46 NX
Colon	32 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	82 NX
Kidney	82 NX

Rod photoreceptor cells	9 NX
Eye	9 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	24 NX
Heart muscle	54 NX
Skin	24 NX
Pancreas	24 NX
Prostate	19 NX

Spermatocytes	20 NX
Testis	20 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	22 NX
Skin	22 NX

Syncytiotrophoblasts	23 NX
Placenta	23 NX

T-cells	18 NX
Skin	22 NX
Kidney	20 NX
Prostate	18 NX
Colon	18 NX
Liver	15 NX
Lung	12 NX

Undifferentiated cells	28 NX
Rectum	31 NX
Small intestine	25 NX
Colon	21 NX

Urothelial cells	17 NX
Prostate	17 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.