Cell type atlas - IDH2 - The Human Protein Atlas

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IDH2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IDH2
Gene descriptionⁱ Full gene name according to HGNC.	Isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells, Cytotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (MOLT-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Cytotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	67 NX
Liver	98 NX
Kidney	71 NX
Colon	63 NX

Basal glandular cells	67 NX
Prostate	67 NX

Basal keratinocytes	35 NX
Skin	35 NX

Bipolar cells	5 NX
Eye	5 NX

Cardiomyocytes	402 NX
Heart muscle	402 NX

Cholangiocytes	104 NX
Liver	104 NX

Ciliated cells	56 NX
Lung	56 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	72 NX
Kidney	72 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	682 NX
Placenta	682 NX

Distal tubular cells	990 NX
Kidney	990 NX

Ductal cells	188 NX
Pancreas	188 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	25 NX
Pancreas	115 NX
Placenta	67 NX
Heart muscle	45 NX
Prostate	41 NX
Eye	38 NX
Skin	23 NX
Lung	20 NX
Liver	16 NX
Testis	15 NX

Enterocytes	54 NX
Small intestine	64 NX
Rectum	42 NX
Colon	41 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	256 NX
Pancreas	256 NX

Extravillous trophoblasts	386 NX
Placenta	386 NX

Fibroblasts	37 NX
Placenta	169 NX
Heart muscle	87 NX
Skin	21 NX
Prostate	20 NX
Lung	3 NX

Glandular cells	190 NX
Prostate	190 NX

Granulocytes	30 NX
Lung	42 NX
Colon	18 NX

Hepatocytes	240 NX
Liver	240 NX

Hofbauer cells	230 NX
Placenta	230 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	59 NX
Rectum	61 NX
Colon	58 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	60 NX
Liver	60 NX

Late spermatids	3 NX
Testis	2 NX

Leydig cells	13 NX
Testis	13 NX

Macrophages	71 NX
Pancreas	192 NX
Prostate	151 NX
Kidney	82 NX
Skin	75 NX
Testis	47 NX
Lung	41 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	96 NX
Pancreas	96 NX

Mucus-secreting cells	122 NX
Small intestine	145 NX
Colon	143 NX
Rectum	102 NX

Muller glia cells	18 NX
Eye	18 NX

Pancreatic endocrine cells	128 NX
Pancreas	128 NX

Paneth cells	132 NX
Small intestine	133 NX
Rectum	132 NX
Colon	23 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	129 NX
Kidney	129 NX

Rod photoreceptor cells	5 NX
Eye	5 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	38 NX
Pancreas	132 NX
Prostate	67 NX
Heart muscle	38 NX
Skin	27 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	59 NX
Skin	59 NX

Syncytiotrophoblasts	479 NX
Placenta	479 NX

T-cells	123 NX
Liver	136 NX
Kidney	132 NX
Colon	123 NX
Skin	64 NX
Prostate	61 NX
Lung	46 NX

Undifferentiated cells	268 NX
Small intestine	389 NX
Colon	268 NX
Rectum	189 NX

Urothelial cells	90 NX
Prostate	90 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.