Cell type atlas - SIAH2 - The Human Protein Atlas

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SIAH2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SIAH2
Gene descriptionⁱ Full gene name according to HGNC.	Siah E3 ubiquitin protein ligase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	4 NX
Lung	4 NX

B-cells	48 NX
Kidney	76 NX
Colon	55 NX
Liver	20 NX

Basal glandular cells	71 NX
Prostate	71 NX

Basal keratinocytes	130 NX
Skin	130 NX

Bipolar cells	40 NX
Eye	40 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	8 NX
Lung	8 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	35 NX
Eye	35 NX

Cytotrophoblasts	145 NX
Placenta	145 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	6 NX
Pancreas	6 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	9 NX
Skin	55 NX
Prostate	52 NX
Eye	19 NX
Heart muscle	15 NX
Placenta	9 NX
Testis	8 NX
Lung	6 NX
Pancreas	4 NX
Liver	2 NX

Enterocytes	26 NX
Colon	28 NX
Rectum	26 NX
Small intestine	22 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	6 NX
Pancreas	6 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	48 NX
Prostate	61 NX
Skin	50 NX
Placenta	27 NX
Heart muscle	10 NX
Lung	9 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	10 NX
Colon	18 NX
Lung	2 NX

Hepatocytes	47 NX
Liver	47 NX

Hofbauer cells	28 NX
Placenta	28 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	37 NX
Colon	41 NX
Rectum	33 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	65 NX
Liver	65 NX

Late spermatids	2 NX
Testis	1 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	28 NX
Prostate	116 NX
Skin	75 NX
Kidney	39 NX
Testis	17 NX
Lung	8 NX
Pancreas	7 NX

Melanocytes	42 NX
Skin	42 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	16 NX
Pancreas	16 NX

Mucus-secreting cells	32 NX
Colon	44 NX
Small intestine	31 NX
Rectum	29 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	9 NX
Pancreas	9 NX

Paneth cells	11 NX
Rectum	29 NX
Small intestine	11 NX
Colon	9 NX

Peritubular cells	29 NX
Testis	29 NX

Proximal tubular cells	13 NX
Kidney	13 NX

Rod photoreceptor cells	2 NX
Eye	2 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	39 NX
Prostate	70 NX
Skin	60 NX
Heart muscle	21 NX
Pancreas	16 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	7 NX
Testis	7 NX

Suprabasal keratinocytes	125 NX
Skin	125 NX

Syncytiotrophoblasts	326 NX
Placenta	326 NX

T-cells	52 NX
Skin	156 NX
Prostate	105 NX
Kidney	71 NX
Colon	67 NX
Liver	31 NX
Lung	10 NX

Undifferentiated cells	30 NX
Rectum	31 NX
Colon	30 NX
Small intestine	18 NX

Urothelial cells	66 NX
Prostate	66 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.