Cell type atlas - PHLDA2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PHLDA2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PHLDA2
Gene descriptionⁱ Full gene name according to HGNC.	Pleckstrin homology like domain family A member 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (myeloid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HDLM-2, PC-3, SK-MEL-30, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	38 NX
Lung	38 NX

B-cells	1 NX
Colon	49 NX
Liver	1 NX
Kidney	0 NX

Basal glandular cells	1363 NX
Prostate	1363 NX

Basal keratinocytes	351 NX
Skin	351 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	3794 NX
Placenta	3794 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	172 NX
Pancreas	172 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	9 NX
Prostate	127 NX
Placenta	115 NX
Skin	62 NX
Pancreas	14 NX
Lung	9 NX
Heart muscle	6 NX
Liver	5 NX
Eye	2 NX
Testis	0 NX

Enterocytes	316 NX
Colon	739 NX
Rectum	164 NX
Small intestine	150 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	128 NX
Pancreas	128 NX

Extravillous trophoblasts	1743 NX
Placenta	1743 NX

Fibroblasts	110 NX
Prostate	295 NX
Placenta	173 NX
Lung	110 NX
Skin	77 NX
Heart muscle	14 NX

Glandular cells	1373 NX
Prostate	1373 NX

Granulocytes	83 NX
Colon	129 NX
Lung	37 NX

Hepatocytes	3 NX
Liver	3 NX

Hofbauer cells	356 NX
Placenta	356 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	189 NX
Colon	319 NX
Rectum	59 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	9 NX
Liver	9 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	3 NX
Testis	3 NX

Macrophages	47 NX
Skin	236 NX
Prostate	212 NX
Pancreas	49 NX
Lung	26 NX
Kidney	22 NX
Testis	12 NX

Melanocytes	98 NX
Skin	98 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	17 NX
Pancreas	17 NX

Mucus-secreting cells	122 NX
Colon	756 NX
Rectum	126 NX
Small intestine	113 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	314 NX
Pancreas	314 NX

Paneth cells	274 NX
Colon	1785 NX
Rectum	274 NX
Small intestine	253 NX

Peritubular cells	3 NX
Testis	3 NX

Proximal tubular cells	0 NX
Kidney	0 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	311 NX
Prostate	534 NX
Pancreas	311 NX
Skin	244 NX
Heart muscle	231 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	599 NX
Skin	599 NX

Syncytiotrophoblasts	8329 NX
Placenta	8329 NX

T-cells	4 NX
Prostate	201 NX
Skin	179 NX
Colon	42 NX
Lung	4 NX
Kidney	4 NX
Liver	0 NX

Undifferentiated cells	109 NX
Colon	396 NX
Rectum	102 NX
Small intestine	89 NX

Urothelial cells	2916 NX
Prostate	2916 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.