Cell type atlas - NPM1 - The Human Protein Atlas

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NPM1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NPM1
Gene descriptionⁱ Full gene name according to HGNC.	Nucleophosmin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	322 NX
Lung	322 NX

Alveolar cells type 2	347 NX
Lung	347 NX

B-cells	776 NX
Liver	862 NX
Kidney	838 NX
Colon	668 NX

Basal glandular cells	994 NX
Prostate	994 NX

Basal keratinocytes	1244 NX
Skin	1244 NX

Bipolar cells	166 NX
Eye	166 NX

Cardiomyocytes	229 NX
Heart muscle	229 NX

Cholangiocytes	387 NX
Liver	387 NX

Ciliated cells	347 NX
Lung	347 NX

Club cells	597 NX
Lung	597 NX

Collecting duct cells	307 NX
Kidney	307 NX

Cone photoreceptor cells	41 NX
Eye	41 NX

Cytotrophoblasts	1401 NX
Placenta	1401 NX

Distal tubular cells	630 NX
Kidney	630 NX

Ductal cells	839 NX
Pancreas	839 NX

Early spermatids	64 NX
Testis	64 NX

Endothelial cells	647 NX
Prostate	908 NX
Placenta	780 NX
Skin	762 NX
Pancreas	720 NX
Testis	647 NX
Lung	417 NX
Liver	400 NX
Eye	222 NX
Heart muscle	175 NX

Enterocytes	151 NX
Small intestine	341 NX
Colon	121 NX
Rectum	112 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	796 NX
Pancreas	796 NX

Extravillous trophoblasts	1642 NX
Placenta	1642 NX

Fibroblasts	855 NX
Lung	1342 NX
Placenta	1093 NX
Prostate	855 NX
Skin	622 NX
Heart muscle	279 NX

Glandular cells	474 NX
Prostate	474 NX

Granulocytes	428 NX
Lung	498 NX
Colon	358 NX

Hepatocytes	236 NX
Liver	236 NX

Hofbauer cells	953 NX
Placenta	953 NX

Horizontal cells	121 NX
Eye	121 NX

Intestinal endocrine cells	348 NX
Colon	384 NX
Rectum	311 NX

Ito cells	298 NX
Liver	298 NX

Kupffer cells	501 NX
Liver	501 NX

Late spermatids	53 NX
Testis	53 NX

Leydig cells	903 NX
Testis	903 NX

Macrophages	606 NX
Skin	723 NX
Prostate	717 NX
Testis	648 NX
Pancreas	564 NX
Kidney	542 NX
Lung	488 NX

Melanocytes	579 NX
Skin	579 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	960 NX
Pancreas	960 NX

Mucus-secreting cells	654 NX
Rectum	691 NX
Colon	680 NX
Small intestine	392 NX

Muller glia cells	215 NX
Eye	215 NX

Pancreatic endocrine cells	841 NX
Pancreas	841 NX

Paneth cells	333 NX
Rectum	530 NX
Small intestine	333 NX
Colon	147 NX

Peritubular cells	611 NX
Testis	611 NX

Proximal tubular cells	658 NX
Kidney	658 NX

Rod photoreceptor cells	112 NX
Eye	112 NX

Sertoli cells	427 NX
Testis	427 NX

Smooth muscle cells	861 NX
Pancreas	1198 NX
Skin	1017 NX
Prostate	841 NX
Heart muscle	250 NX

Spermatocytes	695 NX
Testis	695 NX

Spermatogonia	635 NX
Testis	635 NX

Suprabasal keratinocytes	891 NX
Skin	891 NX

Syncytiotrophoblasts	1287 NX
Placenta	1287 NX

T-cells	675 NX
Skin	1108 NX
Kidney	857 NX
Prostate	824 NX
Colon	675 NX
Liver	593 NX
Lung	483 NX

Undifferentiated cells	783 NX
Small intestine	950 NX
Colon	772 NX
Rectum	600 NX

Urothelial cells	798 NX
Prostate	798 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.