Cell type atlas - PPA1 - The Human Protein Atlas

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PPA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPA1
Gene descriptionⁱ Full gene name according to HGNC.	Pyrophosphatase (inorganic) 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Muller glia cells, monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Muller glia cells, monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	208 NX
Lung	208 NX

Alveolar cells type 2	123 NX
Lung	123 NX

B-cells	139 NX
Liver	190 NX
Colon	172 NX
Kidney	107 NX

Basal glandular cells	261 NX
Prostate	261 NX

Basal keratinocytes	238 NX
Skin	238 NX

Bipolar cells	183 NX
Eye	183 NX

Cardiomyocytes	75 NX
Heart muscle	75 NX

Cholangiocytes	171 NX
Liver	171 NX

Ciliated cells	78 NX
Lung	78 NX

Club cells	179 NX
Lung	179 NX

Collecting duct cells	103 NX
Kidney	103 NX

Cone photoreceptor cells	163 NX
Eye	163 NX

Cytotrophoblasts	266 NX
Placenta	266 NX

Distal tubular cells	171 NX
Kidney	171 NX

Ductal cells	482 NX
Pancreas	482 NX

Early spermatids	21 NX
Testis	21 NX

Endothelial cells	173 NX
Prostate	432 NX
Eye	225 NX
Pancreas	211 NX
Testis	196 NX
Placenta	173 NX
Skin	147 NX
Heart muscle	118 NX
Lung	76 NX
Liver	34 NX

Enterocytes	204 NX
Small intestine	382 NX
Colon	188 NX
Rectum	172 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	679 NX
Pancreas	679 NX

Extravillous trophoblasts	222 NX
Placenta	222 NX

Fibroblasts	156 NX
Prostate	227 NX
Placenta	187 NX
Skin	144 NX
Lung	116 NX
Heart muscle	79 NX

Glandular cells	256 NX
Prostate	256 NX

Granulocytes	37 NX
Colon	55 NX
Lung	19 NX

Hepatocytes	133 NX
Liver	133 NX

Hofbauer cells	93 NX
Placenta	93 NX

Horizontal cells	81 NX
Eye	81 NX

Intestinal endocrine cells	156 NX
Colon	184 NX
Rectum	129 NX

Ito cells	38 NX
Liver	38 NX

Kupffer cells	69 NX
Liver	69 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	102 NX
Testis	102 NX

Macrophages	81 NX
Prostate	230 NX
Kidney	131 NX
Skin	105 NX
Lung	72 NX
Testis	68 NX
Pancreas	54 NX

Melanocytes	172 NX
Skin	172 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	942 NX
Pancreas	942 NX

Mucus-secreting cells	202 NX
Colon	309 NX
Rectum	187 NX
Small intestine	160 NX

Muller glia cells	983 NX
Eye	983 NX

Pancreatic endocrine cells	518 NX
Pancreas	518 NX

Paneth cells	210 NX
Rectum	240 NX
Colon	210 NX
Small intestine	126 NX

Peritubular cells	110 NX
Testis	110 NX

Proximal tubular cells	442 NX
Kidney	442 NX

Rod photoreceptor cells	228 NX
Eye	228 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	157 NX
Prostate	228 NX
Pancreas	224 NX
Skin	138 NX
Heart muscle	19 NX

Spermatocytes	150 NX
Testis	150 NX

Spermatogonia	175 NX
Testis	175 NX

Suprabasal keratinocytes	225 NX
Skin	225 NX

Syncytiotrophoblasts	206 NX
Placenta	206 NX

T-cells	113 NX
Skin	157 NX
Prostate	131 NX
Colon	130 NX
Kidney	126 NX
Liver	63 NX
Lung	59 NX

Undifferentiated cells	280 NX
Colon	380 NX
Rectum	256 NX
Small intestine	251 NX

Urothelial cells	496 NX
Prostate	496 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.