Cell type atlas - HIST1H2AC - The Human Protein Atlas

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HIST1H2AC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIST1H2AC
Gene descriptionⁱ Full gene name according to HGNC.	Histone cluster 1 H2A family member c
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HSkMC, OE19, SiHa, U-2 OS, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	28 NX
Kidney	45 NX
Liver	20 NX
Colon	15 NX

Basal glandular cells	118 NX
Prostate	118 NX

Basal keratinocytes	3 NX
Skin	3 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	23 NX
Heart muscle	23 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	14 NX
Placenta	14 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	19 NX
Pancreas	19 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	18 NX
Placenta	33 NX
Prostate	30 NX
Testis	29 NX
Eye	21 NX
Heart muscle	18 NX
Liver	18 NX
Lung	6 NX
Skin	5 NX
Pancreas	0 NX

Enterocytes	87 NX
Colon	121 NX
Rectum	88 NX
Small intestine	78 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	22 NX
Placenta	22 NX

Fibroblasts	14 NX
Lung	25 NX
Placenta	18 NX
Prostate	16 NX
Heart muscle	14 NX
Skin	5 NX

Glandular cells	178 NX
Prostate	178 NX

Granulocytes	10 NX
Lung	12 NX
Colon	9 NX

Hepatocytes	51 NX
Liver	51 NX

Hofbauer cells	14 NX
Placenta	14 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	93 NX
Rectum	105 NX
Colon	82 NX

Ito cells	16 NX
Liver	16 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	13 NX
Testis	13 NX

Macrophages	8 NX
Prostate	92 NX
Kidney	66 NX
Testis	27 NX
Lung	7 NX
Pancreas	5 NX
Skin	5 NX

Melanocytes	5 NX
Skin	5 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	13 NX
Pancreas	13 NX

Mucus-secreting cells	31 NX
Small intestine	51 NX
Colon	32 NX
Rectum	30 NX

Muller glia cells	11 NX
Eye	11 NX

Pancreatic endocrine cells	34 NX
Pancreas	34 NX

Paneth cells	130 NX
Colon	291 NX
Small intestine	130 NX
Rectum	59 NX

Peritubular cells	7 NX
Testis	7 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	17 NX
Prostate	32 NX
Heart muscle	18 NX
Skin	15 NX
Pancreas	8 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	7 NX
Skin	7 NX

Syncytiotrophoblasts	64 NX
Placenta	64 NX

T-cells	19 NX
Prostate	52 NX
Kidney	26 NX
Skin	19 NX
Liver	19 NX
Colon	17 NX
Lung	12 NX

Undifferentiated cells	26 NX
Colon	27 NX
Rectum	26 NX
Small intestine	20 NX

Urothelial cells	208 NX
Prostate	208 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.