Cell type atlas - CCDC66 - The Human Protein Atlas

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CCDC66

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCDC66
Gene descriptionⁱ Full gene name according to HGNC.	Coiled-coil domain containing 66
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	25 NX
Kidney	49 NX
Liver	25 NX
Colon	15 NX

Basal glandular cells	21 NX
Prostate	21 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	67 NX
Eye	67 NX

Cardiomyocytes	27 NX
Heart muscle	27 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	102 NX
Eye	102 NX

Cytotrophoblasts	18 NX
Placenta	18 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	17 NX
Pancreas	17 NX

Early spermatids	159 NX
Testis	159 NX

Endothelial cells	29 NX
Liver	41 NX
Testis	34 NX
Skin	32 NX
Heart muscle	30 NX
Prostate	30 NX
Pancreas	29 NX
Eye	26 NX
Placenta	23 NX
Lung	20 NX

Enterocytes	8 NX
Small intestine	10 NX
Rectum	6 NX
Colon	4 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	9 NX
Pancreas	9 NX

Extravillous trophoblasts	11 NX
Placenta	11 NX

Fibroblasts	30 NX
Skin	41 NX
Heart muscle	31 NX
Prostate	30 NX
Placenta	24 NX
Lung	8 NX

Glandular cells	13 NX
Prostate	13 NX

Granulocytes	34 NX
Colon	37 NX
Lung	30 NX

Hepatocytes	8 NX
Liver	8 NX

Hofbauer cells	16 NX
Placenta	16 NX

Horizontal cells	49 NX
Eye	49 NX

Intestinal endocrine cells	20 NX
Rectum	23 NX
Colon	17 NX

Ito cells	27 NX
Liver	27 NX

Kupffer cells	26 NX
Liver	26 NX

Late spermatids	74 NX
Testis	74 NX

Leydig cells	50 NX
Testis	50 NX

Macrophages	21 NX
Testis	47 NX
Skin	28 NX
Kidney	25 NX
Lung	16 NX
Pancreas	14 NX
Prostate	12 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	43 NX
Pancreas	43 NX

Mucus-secreting cells	9 NX
Small intestine	14 NX
Rectum	10 NX
Colon	9 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	14 NX
Pancreas	14 NX

Paneth cells	10 NX
Small intestine	14 NX
Rectum	10 NX
Colon	3 NX

Peritubular cells	45 NX
Testis	45 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	100 NX
Eye	100 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	30 NX
Skin	38 NX
Heart muscle	30 NX
Prostate	22 NX
Pancreas	16 NX

Spermatocytes	50 NX
Testis	50 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	14 NX
Placenta	14 NX

T-cells	47 NX
Kidney	53 NX
Prostate	52 NX
Liver	49 NX
Lung	45 NX
Colon	38 NX
Skin	28 NX

Undifferentiated cells	14 NX
Rectum	15 NX
Small intestine	14 NX
Colon	11 NX

Urothelial cells	10 NX
Prostate	10 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.