Cell type atlas - OAZ2 - The Human Protein Atlas

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OAZ2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OAZ2
Gene descriptionⁱ Full gene name according to HGNC.	Ornithine decarboxylase antizyme 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Sertoli cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Sertoli cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	38 NX
Lung	38 NX

B-cells	46 NX
Colon	73 NX
Kidney	40 NX
Liver	39 NX

Basal glandular cells	91 NX
Prostate	91 NX

Basal keratinocytes	108 NX
Skin	108 NX

Bipolar cells	94 NX
Eye	94 NX

Cardiomyocytes	54 NX
Heart muscle	54 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	30 NX
Lung	30 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	98 NX
Eye	98 NX

Cytotrophoblasts	96 NX
Placenta	96 NX

Distal tubular cells	143 NX
Kidney	143 NX

Ductal cells	95 NX
Pancreas	95 NX

Early spermatids	297 NX
Testis	297 NX

Endothelial cells	107 NX
Skin	173 NX
Pancreas	168 NX
Placenta	126 NX
Prostate	125 NX
Testis	122 NX
Eye	107 NX
Liver	79 NX
Heart muscle	48 NX
Lung	38 NX

Enterocytes	17 NX
Small intestine	25 NX
Rectum	21 NX
Colon	13 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	58 NX
Pancreas	58 NX

Extravillous trophoblasts	59 NX
Placenta	59 NX

Fibroblasts	101 NX
Skin	106 NX
Placenta	106 NX
Prostate	92 NX
Heart muscle	41 NX
Lung	33 NX

Glandular cells	71 NX
Prostate	71 NX

Granulocytes	101 NX
Colon	101 NX
Lung	100 NX

Hepatocytes	74 NX
Liver	74 NX

Hofbauer cells	120 NX
Placenta	120 NX

Horizontal cells	70 NX
Eye	70 NX

Intestinal endocrine cells	79 NX
Colon	92 NX
Rectum	66 NX

Ito cells	83 NX
Liver	83 NX

Kupffer cells	98 NX
Liver	98 NX

Late spermatids	56 NX
Testis	56 NX

Leydig cells	106 NX
Testis	106 NX

Macrophages	126 NX
Pancreas	183 NX
Skin	169 NX
Prostate	147 NX
Kidney	142 NX
Testis	57 NX
Lung	33 NX

Melanocytes	98 NX
Skin	98 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	90 NX
Pancreas	90 NX

Mucus-secreting cells	28 NX
Rectum	29 NX
Small intestine	25 NX
Colon	15 NX

Muller glia cells	212 NX
Eye	212 NX

Pancreatic endocrine cells	71 NX
Pancreas	71 NX

Paneth cells	30 NX
Small intestine	35 NX
Rectum	30 NX
Colon	6 NX

Peritubular cells	64 NX
Testis	64 NX

Proximal tubular cells	71 NX
Kidney	71 NX

Rod photoreceptor cells	149 NX
Eye	149 NX

Sertoli cells	369 NX
Testis	369 NX

Smooth muscle cells	196 NX
Skin	293 NX
Prostate	196 NX
Heart muscle	123 NX
Pancreas	116 NX

Spermatocytes	123 NX
Testis	123 NX

Spermatogonia	55 NX
Testis	55 NX

Suprabasal keratinocytes	106 NX
Skin	106 NX

Syncytiotrophoblasts	57 NX
Placenta	57 NX

T-cells	35 NX
Prostate	74 NX
Skin	59 NX
Liver	39 NX
Kidney	35 NX
Colon	35 NX
Lung	30 NX

Undifferentiated cells	26 NX
Small intestine	33 NX
Rectum	28 NX
Colon	20 NX

Urothelial cells	61 NX
Prostate	61 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.