Cell type atlas - PDXDC1 - The Human Protein Atlas

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PDXDC1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDXDC1
Gene descriptionⁱ Full gene name according to HGNC.	Pyridoxal dependent decarboxylase domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	64 NX
Lung	64 NX

B-cells	44 NX
Liver	57 NX
Colon	33 NX
Kidney	22 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	34 NX
Skin	34 NX

Bipolar cells	30 NX
Eye	30 NX

Cardiomyocytes	38 NX
Heart muscle	38 NX

Cholangiocytes	77 NX
Liver	77 NX

Ciliated cells	54 NX
Lung	54 NX

Club cells	60 NX
Lung	60 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	42 NX
Placenta	42 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	33 NX
Pancreas	33 NX

Early spermatids	401 NX
Testis	401 NX

Endothelial cells	31 NX
Testis	53 NX
Lung	53 NX
Prostate	51 NX
Skin	36 NX
Eye	31 NX
Pancreas	29 NX
Heart muscle	26 NX
Liver	22 NX
Placenta	16 NX

Enterocytes	116 NX
Colon	149 NX
Rectum	119 NX
Small intestine	97 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	51 NX
Pancreas	51 NX

Extravillous trophoblasts	47 NX
Placenta	47 NX

Fibroblasts	36 NX
Lung	50 NX
Prostate	40 NX
Placenta	38 NX
Heart muscle	36 NX
Skin	28 NX

Glandular cells	61 NX
Prostate	61 NX

Granulocytes	38 NX
Lung	40 NX
Colon	37 NX

Hepatocytes	114 NX
Liver	114 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	38 NX
Eye	38 NX

Intestinal endocrine cells	155 NX
Colon	160 NX
Rectum	150 NX

Ito cells	28 NX
Liver	28 NX

Kupffer cells	34 NX
Liver	34 NX

Late spermatids	548 NX
Testis	548 NX

Leydig cells	46 NX
Testis	46 NX

Macrophages	28 NX
Testis	38 NX
Lung	33 NX
Pancreas	30 NX
Prostate	25 NX
Kidney	17 NX
Skin	12 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	186 NX
Colon	260 NX
Rectum	192 NX
Small intestine	153 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	111 NX
Colon	124 NX
Rectum	111 NX
Small intestine	74 NX

Peritubular cells	43 NX
Testis	43 NX

Proximal tubular cells	36 NX
Kidney	36 NX

Rod photoreceptor cells	49 NX
Eye	49 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	23 NX
Prostate	45 NX
Pancreas	26 NX
Heart muscle	23 NX
Skin	20 NX

Spermatocytes	134 NX
Testis	134 NX

Spermatogonia	71 NX
Testis	71 NX

Suprabasal keratinocytes	37 NX
Skin	37 NX

Syncytiotrophoblasts	68 NX
Placenta	68 NX

T-cells	33 NX
Colon	43 NX
Lung	42 NX
Skin	33 NX
Liver	30 NX
Prostate	22 NX
Kidney	14 NX

Undifferentiated cells	95 NX
Colon	142 NX
Rectum	108 NX
Small intestine	81 NX

Urothelial cells	51 NX
Prostate	51 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.