Cell type atlas - CLK3 - The Human Protein Atlas

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CLK3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLK3
Gene descriptionⁱ Full gene name according to HGNC.	CDC like kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	21 NX
Kidney	36 NX
Colon	25 NX
Liver	8 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	40 NX
Skin	40 NX

Bipolar cells	35 NX
Eye	35 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	18 NX
Lung	18 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	53 NX
Eye	53 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	27 NX
Kidney	27 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	60 NX
Testis	60 NX

Endothelial cells	28 NX
Prostate	45 NX
Eye	31 NX
Heart muscle	31 NX
Placenta	30 NX
Skin	26 NX
Liver	22 NX
Testis	20 NX
Pancreas	18 NX
Lung	18 NX

Enterocytes	37 NX
Colon	54 NX
Rectum	29 NX
Small intestine	28 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	31 NX
Placenta	31 NX

Fibroblasts	23 NX
Prostate	41 NX
Placenta	28 NX
Skin	23 NX
Heart muscle	17 NX
Lung	14 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	21 NX
Lung	23 NX
Colon	18 NX

Hepatocytes	11 NX
Liver	11 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	28 NX
Colon	31 NX
Rectum	26 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	24 NX
Liver	24 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	29 NX
Prostate	50 NX
Lung	34 NX
Testis	29 NX
Pancreas	28 NX
Skin	24 NX
Kidney	22 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	25 NX
Colon	41 NX
Small intestine	32 NX
Rectum	22 NX

Muller glia cells	18 NX
Eye	18 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	28 NX
Colon	83 NX
Rectum	28 NX
Small intestine	28 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	14 NX
Kidney	14 NX

Rod photoreceptor cells	42 NX
Eye	42 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	24 NX
Heart muscle	37 NX
Prostate	36 NX
Pancreas	24 NX
Skin	21 NX

Spermatocytes	37 NX
Testis	37 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	37 NX
Skin	37 NX

Syncytiotrophoblasts	49 NX
Placenta	49 NX

T-cells	39 NX
Skin	48 NX
Lung	42 NX
Colon	40 NX
Prostate	39 NX
Kidney	37 NX
Liver	35 NX

Undifferentiated cells	23 NX
Colon	30 NX
Small intestine	23 NX
Rectum	21 NX

Urothelial cells	53 NX
Prostate	53 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.