Cell type atlas - KCTD12 - The Human Protein Atlas

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KCTD12

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KCTD12
Gene descriptionⁱ Full gene name according to HGNC.	Potassium channel tetramerization domain containing 12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, Intestinal endocrine cells, Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (classical monocyte, myeloid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells, Intestinal endocrine cells, Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	10 NX
Lung	10 NX

B-cells	7 NX
Colon	16 NX
Liver	7 NX
Kidney	0 NX

Basal glandular cells	3 NX
Prostate	3 NX

Basal keratinocytes	36 NX
Skin	36 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	3 NX
Liver	3 NX

Ciliated cells	116 NX
Lung	116 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	93 NX
Kidney	93 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	3 NX
Placenta	3 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	3 NX
Pancreas	3 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	150 NX
Testis	418 NX
Skin	298 NX
Heart muscle	249 NX
Lung	181 NX
Eye	132 NX
Prostate	106 NX
Placenta	77 NX
Pancreas	29 NX
Liver	20 NX

Enterocytes	3 NX
Rectum	15 NX
Colon	4 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	1 NX
Pancreas	1 NX

Extravillous trophoblasts	83 NX
Placenta	83 NX

Fibroblasts	78 NX
Skin	115 NX
Placenta	88 NX
Heart muscle	63 NX
Lung	29 NX
Prostate	12 NX

Glandular cells	3 NX
Prostate	3 NX

Granulocytes	7 NX
Colon	9 NX
Lung	5 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	181 NX
Placenta	181 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	372 NX
Rectum	386 NX
Colon	357 NX

Ito cells	47 NX
Liver	47 NX

Kupffer cells	375 NX
Liver	375 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	146 NX
Testis	146 NX

Macrophages	119 NX
Testis	469 NX
Prostate	188 NX
Kidney	126 NX
Lung	120 NX
Skin	87 NX
Pancreas	42 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3 NX
Pancreas	3 NX

Mucus-secreting cells	71 NX
Rectum	103 NX
Small intestine	52 NX
Colon	38 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	1 NX
Pancreas	1 NX

Paneth cells	0 NX
Rectum	43 NX
Colon	0 NX
Small intestine	0 NX

Peritubular cells	42 NX
Testis	42 NX

Proximal tubular cells	5 NX
Kidney	5 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	27 NX
Skin	47 NX
Heart muscle	38 NX
Prostate	9 NX
Pancreas	8 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	30 NX
Skin	30 NX

Syncytiotrophoblasts	4 NX
Placenta	4 NX

T-cells	2 NX
Skin	22 NX
Lung	9 NX
Kidney	3 NX
Colon	2 NX
Liver	1 NX
Prostate	0 NX

Undifferentiated cells	49 NX
Rectum	78 NX
Colon	32 NX
Small intestine	3 NX

Urothelial cells	1 NX
Prostate	1 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.