Cell type atlas - SUZ12 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SUZ12

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SUZ12
Gene descriptionⁱ Full gene name according to HGNC.	SUZ12 polycomb repressive complex 2 subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	38 NX
Lung	38 NX

B-cells	23 NX
Liver	34 NX
Kidney	27 NX
Colon	19 NX

Basal glandular cells	41 NX
Prostate	41 NX

Basal keratinocytes	52 NX
Skin	52 NX

Bipolar cells	74 NX
Eye	74 NX

Cardiomyocytes	25 NX
Heart muscle	25 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	28 NX
Lung	28 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	102 NX
Eye	102 NX

Cytotrophoblasts	49 NX
Placenta	49 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	24 NX
Pancreas	24 NX

Early spermatids	9 NX
Testis	9 NX

Endothelial cells	35 NX
Prostate	56 NX
Eye	48 NX
Skin	46 NX
Heart muscle	35 NX
Testis	35 NX
Placenta	33 NX
Liver	27 NX
Pancreas	25 NX
Lung	20 NX

Enterocytes	16 NX
Rectum	27 NX
Small intestine	19 NX
Colon	12 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	19 NX
Pancreas	19 NX

Extravillous trophoblasts	46 NX
Placenta	46 NX

Fibroblasts	34 NX
Prostate	52 NX
Skin	35 NX
Placenta	30 NX
Lung	27 NX
Heart muscle	27 NX

Glandular cells	46 NX
Prostate	46 NX

Granulocytes	15 NX
Lung	21 NX
Colon	9 NX

Hepatocytes	38 NX
Liver	38 NX

Hofbauer cells	28 NX
Placenta	28 NX

Horizontal cells	59 NX
Eye	59 NX

Intestinal endocrine cells	28 NX
Rectum	33 NX
Colon	24 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	42 NX
Liver	42 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	25 NX
Testis	25 NX

Macrophages	38 NX
Lung	46 NX
Prostate	43 NX
Skin	40 NX
Testis	33 NX
Kidney	27 NX
Pancreas	26 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	87 NX
Pancreas	87 NX

Mucus-secreting cells	32 NX
Rectum	35 NX
Small intestine	28 NX
Colon	21 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	23 NX
Pancreas	23 NX

Paneth cells	11 NX
Rectum	23 NX
Small intestine	11 NX
Colon	9 NX

Peritubular cells	24 NX
Testis	24 NX

Proximal tubular cells	25 NX
Kidney	25 NX

Rod photoreceptor cells	76 NX
Eye	76 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	33 NX
Skin	39 NX
Prostate	36 NX
Heart muscle	26 NX
Pancreas	26 NX

Spermatocytes	101 NX
Testis	101 NX

Spermatogonia	141 NX
Testis	141 NX

Suprabasal keratinocytes	63 NX
Skin	63 NX

Syncytiotrophoblasts	58 NX
Placenta	58 NX

T-cells	40 NX
Prostate	52 NX
Kidney	42 NX
Colon	40 NX
Liver	34 NX
Skin	30 NX
Lung	27 NX

Undifferentiated cells	33 NX
Small intestine	34 NX
Rectum	33 NX
Colon	22 NX

Urothelial cells	48 NX
Prostate	48 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.