Cell type atlas - UBE2N - The Human Protein Atlas

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UBE2N

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBE2N
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin conjugating enzyme E2 N
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	45 NX
Lung	45 NX

B-cells	138 NX
Colon	175 NX
Kidney	160 NX
Liver	86 NX

Basal glandular cells	175 NX
Prostate	175 NX

Basal keratinocytes	286 NX
Skin	286 NX

Bipolar cells	65 NX
Eye	65 NX

Cardiomyocytes	71 NX
Heart muscle	71 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	63 NX
Lung	63 NX

Club cells	66 NX
Lung	66 NX

Collecting duct cells	86 NX
Kidney	86 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	212 NX
Placenta	212 NX

Distal tubular cells	163 NX
Kidney	163 NX

Ductal cells	138 NX
Pancreas	138 NX

Early spermatids	2177 NX
Testis	2177 NX

Endothelial cells	84 NX
Prostate	168 NX
Skin	154 NX
Placenta	114 NX
Pancreas	100 NX
Testis	84 NX
Lung	64 NX
Heart muscle	56 NX
Liver	49 NX
Eye	48 NX

Enterocytes	62 NX
Rectum	70 NX
Colon	64 NX
Small intestine	51 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	87 NX
Pancreas	87 NX

Extravillous trophoblasts	188 NX
Placenta	188 NX

Fibroblasts	124 NX
Prostate	188 NX
Skin	157 NX
Placenta	114 NX
Lung	72 NX
Heart muscle	53 NX

Glandular cells	118 NX
Prostate	118 NX

Granulocytes	92 NX
Colon	110 NX
Lung	74 NX

Hepatocytes	45 NX
Liver	45 NX

Hofbauer cells	144 NX
Placenta	144 NX

Horizontal cells	83 NX
Eye	83 NX

Intestinal endocrine cells	72 NX
Colon	85 NX
Rectum	59 NX

Ito cells	46 NX
Liver	46 NX

Kupffer cells	59 NX
Liver	59 NX

Late spermatids	6553 NX
Testis	6553 NX

Leydig cells	87 NX
Testis	87 NX

Macrophages	108 NX
Skin	167 NX
Pancreas	133 NX
Kidney	111 NX
Testis	106 NX
Prostate	98 NX
Lung	62 NX

Melanocytes	140 NX
Skin	140 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	201 NX
Pancreas	201 NX

Mucus-secreting cells	50 NX
Colon	107 NX
Rectum	50 NX
Small intestine	46 NX

Muller glia cells	88 NX
Eye	88 NX

Pancreatic endocrine cells	107 NX
Pancreas	107 NX

Paneth cells	78 NX
Small intestine	88 NX
Colon	78 NX
Rectum	62 NX

Peritubular cells	81 NX
Testis	81 NX

Proximal tubular cells	127 NX
Kidney	127 NX

Rod photoreceptor cells	41 NX
Eye	41 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	166 NX
Pancreas	205 NX
Prostate	166 NX
Skin	146 NX
Heart muscle	93 NX

Spermatocytes	247 NX
Testis	247 NX

Spermatogonia	216 NX
Testis	216 NX

Suprabasal keratinocytes	282 NX
Skin	282 NX

Syncytiotrophoblasts	238 NX
Placenta	238 NX

T-cells	122 NX
Skin	155 NX
Kidney	151 NX
Colon	128 NX
Prostate	122 NX
Liver	93 NX
Lung	63 NX

Undifferentiated cells	66 NX
Colon	133 NX
Small intestine	90 NX
Rectum	56 NX

Urothelial cells	191 NX
Prostate	191 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.