Cell type atlas - POLR2L - The Human Protein Atlas

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POLR2L

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLR2L
Gene descriptionⁱ Full gene name according to HGNC.	RNA polymerase II subunit L
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins RNA polymerase related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	381 NX
Lung	381 NX

Alveolar cells type 2	358 NX
Lung	358 NX

B-cells	237 NX
Liver	455 NX
Kidney	258 NX
Colon	215 NX

Basal glandular cells	203 NX
Prostate	203 NX

Basal keratinocytes	543 NX
Skin	543 NX

Bipolar cells	63 NX
Eye	63 NX

Cardiomyocytes	432 NX
Heart muscle	432 NX

Cholangiocytes	640 NX
Liver	640 NX

Ciliated cells	250 NX
Lung	250 NX

Club cells	323 NX
Lung	323 NX

Collecting duct cells	499 NX
Kidney	499 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	588 NX
Placenta	588 NX

Distal tubular cells	1091 NX
Kidney	1091 NX

Ductal cells	435 NX
Pancreas	435 NX

Early spermatids	68 NX
Testis	68 NX

Endothelial cells	337 NX
Liver	931 NX
Skin	831 NX
Placenta	643 NX
Lung	370 NX
Pancreas	337 NX
Testis	235 NX
Prostate	188 NX
Eye	169 NX
Heart muscle	161 NX

Enterocytes	721 NX
Colon	793 NX
Small intestine	686 NX
Rectum	384 NX

Erythroid cells	350 NX
Liver	350 NX

Exocrine glandular cells	588 NX
Pancreas	588 NX

Extravillous trophoblasts	345 NX
Placenta	345 NX

Fibroblasts	533 NX
Skin	745 NX
Placenta	560 NX
Lung	273 NX
Heart muscle	243 NX
Prostate	150 NX

Glandular cells	244 NX
Prostate	244 NX

Granulocytes	260 NX
Colon	276 NX
Lung	244 NX

Hepatocytes	1459 NX
Liver	1459 NX

Hofbauer cells	606 NX
Placenta	606 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	482 NX
Rectum	580 NX
Colon	384 NX

Ito cells	661 NX
Liver	661 NX

Kupffer cells	436 NX
Liver	436 NX

Late spermatids	178 NX
Testis	178 NX

Leydig cells	283 NX
Testis	283 NX

Macrophages	302 NX
Kidney	742 NX
Pancreas	468 NX
Skin	467 NX
Testis	200 NX
Lung	199 NX
Prostate	136 NX

Melanocytes	624 NX
Skin	624 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	530 NX
Pancreas	530 NX

Mucus-secreting cells	452 NX
Colon	783 NX
Small intestine	448 NX
Rectum	421 NX

Muller glia cells	187 NX
Eye	187 NX

Pancreatic endocrine cells	631 NX
Pancreas	631 NX

Paneth cells	463 NX
Colon	760 NX
Small intestine	463 NX
Rectum	364 NX

Peritubular cells	240 NX
Testis	240 NX

Proximal tubular cells	1294 NX
Kidney	1294 NX

Rod photoreceptor cells	56 NX
Eye	56 NX

Sertoli cells	155 NX
Testis	155 NX

Smooth muscle cells	447 NX
Pancreas	719 NX
Skin	476 NX
Heart muscle	194 NX
Prostate	187 NX

Spermatocytes	175 NX
Testis	175 NX

Spermatogonia	249 NX
Testis	249 NX

Suprabasal keratinocytes	609 NX
Skin	609 NX

Syncytiotrophoblasts	376 NX
Placenta	376 NX

T-cells	284 NX
Kidney	413 NX
Skin	380 NX
Colon	301 NX
Liver	256 NX
Lung	200 NX
Prostate	105 NX

Undifferentiated cells	423 NX
Colon	627 NX
Rectum	423 NX
Small intestine	397 NX

Urothelial cells	251 NX
Prostate	251 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.