Cell type atlas - C8orf59 - The Human Protein Atlas

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C8orf59

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	C8orf59
Gene descriptionⁱ Full gene name according to HGNC.	Chromosome 8 open reading frame 59
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	65 NX
Lung	65 NX

B-cells	124 NX
Liver	191 NX
Colon	122 NX
Kidney	54 NX

Basal glandular cells	47 NX
Prostate	47 NX

Basal keratinocytes	48 NX
Skin	48 NX

Bipolar cells	26 NX
Eye	26 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	87 NX
Liver	87 NX

Ciliated cells	147 NX
Lung	147 NX

Club cells	104 NX
Lung	104 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	87 NX
Placenta	87 NX

Distal tubular cells	56 NX
Kidney	56 NX

Ductal cells	152 NX
Pancreas	152 NX

Early spermatids	94 NX
Testis	94 NX

Endothelial cells	67 NX
Testis	156 NX
Pancreas	136 NX
Liver	115 NX
Placenta	87 NX
Eye	71 NX
Skin	59 NX
Lung	55 NX
Prostate	32 NX
Heart muscle	15 NX

Enterocytes	77 NX
Small intestine	92 NX
Rectum	74 NX
Colon	64 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	240 NX
Pancreas	240 NX

Extravillous trophoblasts	102 NX
Placenta	102 NX

Fibroblasts	84 NX
Lung	159 NX
Placenta	95 NX
Skin	78 NX
Prostate	32 NX
Heart muscle	23 NX

Glandular cells	40 NX
Prostate	40 NX

Granulocytes	75 NX
Lung	77 NX
Colon	74 NX

Hepatocytes	136 NX
Liver	136 NX

Hofbauer cells	91 NX
Placenta	91 NX

Horizontal cells	22 NX
Eye	22 NX

Intestinal endocrine cells	37 NX
Rectum	40 NX
Colon	34 NX

Ito cells	109 NX
Liver	109 NX

Kupffer cells	132 NX
Liver	132 NX

Late spermatids	21 NX
Testis	21 NX

Leydig cells	173 NX
Testis	173 NX

Macrophages	92 NX
Testis	181 NX
Skin	115 NX
Pancreas	110 NX
Lung	92 NX
Kidney	83 NX
Prostate	42 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	180 NX
Pancreas	180 NX

Mucus-secreting cells	113 NX
Rectum	130 NX
Colon	124 NX
Small intestine	75 NX

Muller glia cells	58 NX
Eye	58 NX

Pancreatic endocrine cells	214 NX
Pancreas	214 NX

Paneth cells	84 NX
Rectum	132 NX
Small intestine	84 NX
Colon	81 NX

Peritubular cells	122 NX
Testis	122 NX

Proximal tubular cells	91 NX
Kidney	91 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	155 NX
Testis	155 NX

Smooth muscle cells	89 NX
Pancreas	115 NX
Skin	93 NX
Prostate	38 NX
Heart muscle	29 NX

Spermatocytes	128 NX
Testis	128 NX

Spermatogonia	92 NX
Testis	92 NX

Suprabasal keratinocytes	40 NX
Skin	40 NX

Syncytiotrophoblasts	64 NX
Placenta	64 NX

T-cells	105 NX
Lung	109 NX
Skin	108 NX
Liver	105 NX
Kidney	87 NX
Colon	78 NX
Prostate	44 NX

Undifferentiated cells	102 NX
Rectum	129 NX
Small intestine	92 NX
Colon	92 NX

Urothelial cells	39 NX
Prostate	39 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.