Cell type atlas - CCDC57 - The Human Protein Atlas

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CCDC57

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCDC57
Gene descriptionⁱ Full gene name according to HGNC.	Coiled-coil domain containing 57
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive CD8 T-cell, naive CD4 T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	61 NX
Lung	61 NX

B-cells	37 NX
Liver	44 NX
Colon	33 NX
Kidney	31 NX

Basal glandular cells	20 NX
Prostate	20 NX

Basal keratinocytes	10 NX
Skin	10 NX

Bipolar cells	20 NX
Eye	20 NX

Cardiomyocytes	3 NX
Heart muscle	3 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	14 NX
Pancreas	14 NX

Early spermatids	115 NX
Testis	115 NX

Endothelial cells	6 NX
Lung	12 NX
Placenta	7 NX
Liver	7 NX
Eye	6 NX
Heart muscle	6 NX
Skin	5 NX
Testis	5 NX
Prostate	4 NX
Pancreas	4 NX

Enterocytes	26 NX
Colon	33 NX
Small intestine	29 NX
Rectum	16 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	16 NX
Pancreas	15 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	8 NX
Lung	20 NX
Placenta	9 NX
Skin	8 NX
Prostate	6 NX
Heart muscle	3 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	35 NX
Colon	46 NX
Lung	23 NX

Hepatocytes	87 NX
Liver	87 NX

Hofbauer cells	26 NX
Placenta	26 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	41 NX
Rectum	52 NX
Colon	31 NX

Ito cells	8 NX
Liver	8 NX

Kupffer cells	36 NX
Liver	36 NX

Late spermatids	565 NX
Testis	565 NX

Leydig cells	8 NX
Testis	8 NX

Macrophages	31 NX
Lung	45 NX
Kidney	37 NX
Skin	35 NX
Prostate	30 NX
Testis	25 NX
Pancreas	19 NX

Melanocytes	32 NX
Skin	32 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	26 NX
Pancreas	26 NX

Mucus-secreting cells	35 NX
Colon	51 NX
Small intestine	39 NX
Rectum	30 NX

Muller glia cells	10 NX
Eye	10 NX

Pancreatic endocrine cells	14 NX
Pancreas	14 NX

Paneth cells	23 NX
Colon	32 NX
Rectum	23 NX
Small intestine	18 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	8 NX
Kidney	8 NX

Rod photoreceptor cells	66 NX
Eye	66 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	10 NX
Heart muscle	12 NX
Skin	12 NX
Prostate	6 NX
Pancreas	3 NX

Spermatocytes	11 NX
Testis	11 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	16 NX
Skin	16 NX

Syncytiotrophoblasts	10 NX
Placenta	10 NX

T-cells	41 NX
Skin	61 NX
Colon	51 NX
Liver	46 NX
Kidney	40 NX
Lung	35 NX
Prostate	4 NX

Undifferentiated cells	27 NX
Small intestine	48 NX
Colon	27 NX
Rectum	22 NX

Urothelial cells	15 NX
Prostate	15 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.