Cell type atlas - YES1 - The Human Protein Atlas

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YES1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YES1
Gene descriptionⁱ Full gene name according to HGNC.	YES proto-oncogene 1, Src family tyrosine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	2 NX
Colon	3 NX
Liver	3 NX
Kidney	0 NX

Basal glandular cells	34 NX
Prostate	34 NX

Basal keratinocytes	53 NX
Skin	53 NX

Bipolar cells	6 NX
Eye	6 NX

Cardiomyocytes	17 NX
Heart muscle	17 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	34 NX
Lung	34 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	26 NX
Pancreas	26 NX

Early spermatids	20 NX
Testis	20 NX

Endothelial cells	78 NX
Prostate	145 NX
Lung	93 NX
Pancreas	93 NX
Skin	85 NX
Placenta	78 NX
Heart muscle	66 NX
Testis	46 NX
Eye	44 NX
Liver	43 NX

Enterocytes	27 NX
Rectum	46 NX
Small intestine	27 NX
Colon	25 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	31 NX
Prostate	47 NX
Lung	36 NX
Skin	33 NX
Heart muscle	31 NX
Placenta	15 NX

Glandular cells	52 NX
Prostate	52 NX

Granulocytes	13 NX
Lung	26 NX
Colon	0 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	4 NX
Placenta	4 NX

Horizontal cells	3 NX
Eye	3 NX

Intestinal endocrine cells	22 NX
Rectum	23 NX
Colon	20 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	6 NX
Liver	6 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	17 NX
Testis	17 NX

Macrophages	5 NX
Skin	10 NX
Lung	7 NX
Pancreas	5 NX
Kidney	4 NX
Prostate	2 NX
Testis	1 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1 NX
Pancreas	1 NX

Mucus-secreting cells	36 NX
Rectum	38 NX
Small intestine	33 NX
Colon	27 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	40 NX
Pancreas	40 NX

Paneth cells	21 NX
Rectum	37 NX
Small intestine	21 NX
Colon	20 NX

Peritubular cells	12 NX
Testis	12 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	8 NX
Eye	8 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	21 NX
Prostate	31 NX
Skin	22 NX
Heart muscle	19 NX
Pancreas	14 NX

Spermatocytes	13 NX
Testis	13 NX

Spermatogonia	12 NX
Testis	12 NX

Suprabasal keratinocytes	43 NX
Skin	43 NX

Syncytiotrophoblasts	38 NX
Placenta	38 NX

T-cells	15 NX
Colon	32 NX
Prostate	31 NX
Liver	16 NX
Lung	14 NX
Kidney	11 NX
Skin	7 NX

Undifferentiated cells	31 NX
Rectum	34 NX
Small intestine	30 NX
Colon	30 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.