Cell type atlas - RAB6A - The Human Protein Atlas

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RAB6A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RAB6A
Gene descriptionⁱ Full gene name according to HGNC.	RAB6A, member RAS oncogene family
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	45 NX
Lung	45 NX

B-cells	43 NX
Colon	70 NX
Kidney	54 NX
Liver	23 NX

Basal glandular cells	42 NX
Prostate	42 NX

Basal keratinocytes	74 NX
Skin	74 NX

Bipolar cells	47 NX
Eye	47 NX

Cardiomyocytes	59 NX
Heart muscle	59 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	65 NX
Kidney	65 NX

Cone photoreceptor cells	83 NX
Eye	83 NX

Cytotrophoblasts	84 NX
Placenta	84 NX

Distal tubular cells	37 NX
Kidney	37 NX

Ductal cells	59 NX
Pancreas	59 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	82 NX
Skin	109 NX
Prostate	100 NX
Heart muscle	89 NX
Pancreas	82 NX
Liver	79 NX
Lung	76 NX
Testis	66 NX
Placenta	53 NX
Eye	47 NX

Enterocytes	80 NX
Small intestine	94 NX
Rectum	81 NX
Colon	65 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	44 NX
Pancreas	44 NX

Extravillous trophoblasts	131 NX
Placenta	131 NX

Fibroblasts	65 NX
Skin	91 NX
Prostate	68 NX
Heart muscle	65 NX
Placenta	56 NX
Lung	44 NX

Glandular cells	49 NX
Prostate	49 NX

Granulocytes	47 NX
Lung	49 NX
Colon	46 NX

Hepatocytes	60 NX
Liver	60 NX

Hofbauer cells	57 NX
Placenta	57 NX

Horizontal cells	38 NX
Eye	38 NX

Intestinal endocrine cells	50 NX
Colon	65 NX
Rectum	35 NX

Ito cells	68 NX
Liver	68 NX

Kupffer cells	54 NX
Liver	54 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	49 NX
Testis	49 NX

Macrophages	56 NX
Skin	67 NX
Prostate	66 NX
Testis	58 NX
Lung	53 NX
Kidney	43 NX
Pancreas	42 NX

Melanocytes	69 NX
Skin	69 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	77 NX
Pancreas	77 NX

Mucus-secreting cells	56 NX
Colon	64 NX
Small intestine	52 NX
Rectum	47 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	61 NX
Pancreas	61 NX

Paneth cells	49 NX
Colon	72 NX
Rectum	49 NX
Small intestine	46 NX

Peritubular cells	58 NX
Testis	58 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	64 NX
Prostate	75 NX
Skin	73 NX
Pancreas	58 NX
Heart muscle	52 NX

Spermatocytes	31 NX
Testis	31 NX

Spermatogonia	34 NX
Testis	34 NX

Suprabasal keratinocytes	99 NX
Skin	99 NX

Syncytiotrophoblasts	145 NX
Placenta	145 NX

T-cells	59 NX
Colon	79 NX
Prostate	74 NX
Skin	73 NX
Liver	53 NX
Kidney	48 NX
Lung	40 NX

Undifferentiated cells	44 NX
Rectum	49 NX
Colon	45 NX
Small intestine	41 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.