Cell type atlas - CLTB - The Human Protein Atlas

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CLTB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLTB
Gene descriptionⁱ Full gene name according to HGNC.	Clathrin light chain B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HBEC3-KT, MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	58 NX
Colon	76 NX
Kidney	62 NX
Liver	34 NX

Basal glandular cells	197 NX
Prostate	197 NX

Basal keratinocytes	563 NX
Skin	563 NX

Bipolar cells	276 NX
Eye	276 NX

Cardiomyocytes	186 NX
Heart muscle	186 NX

Cholangiocytes	74 NX
Liver	74 NX

Ciliated cells	9 NX
Lung	9 NX

Club cells	30 NX
Lung	30 NX

Collecting duct cells	79 NX
Kidney	79 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	110 NX
Placenta	110 NX

Distal tubular cells	114 NX
Kidney	114 NX

Ductal cells	340 NX
Pancreas	340 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	90 NX
Skin	201 NX
Prostate	161 NX
Pancreas	143 NX
Eye	90 NX
Testis	78 NX
Heart muscle	70 NX
Placenta	61 NX
Liver	49 NX
Lung	9 NX

Enterocytes	537 NX
Colon	969 NX
Rectum	578 NX
Small intestine	452 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	398 NX
Pancreas	398 NX

Extravillous trophoblasts	475 NX
Placenta	475 NX

Fibroblasts	139 NX
Skin	219 NX
Prostate	204 NX
Heart muscle	111 NX
Placenta	75 NX
Lung	16 NX

Glandular cells	165 NX
Prostate	165 NX

Granulocytes	48 NX
Colon	74 NX
Lung	23 NX

Hepatocytes	90 NX
Liver	90 NX

Hofbauer cells	100 NX
Placenta	100 NX

Horizontal cells	318 NX
Eye	318 NX

Intestinal endocrine cells	146 NX
Colon	177 NX
Rectum	115 NX

Ito cells	59 NX
Liver	59 NX

Kupffer cells	81 NX
Liver	80 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	113 NX
Testis	113 NX

Macrophages	120 NX
Skin	184 NX
Pancreas	145 NX
Kidney	140 NX
Prostate	101 NX
Testis	73 NX
Lung	14 NX

Melanocytes	209 NX
Skin	209 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	74 NX
Pancreas	74 NX

Mucus-secreting cells	265 NX
Colon	482 NX
Small intestine	276 NX
Rectum	153 NX

Muller glia cells	89 NX
Eye	89 NX

Pancreatic endocrine cells	1145 NX
Pancreas	1145 NX

Paneth cells	526 NX
Colon	1313 NX
Small intestine	526 NX
Rectum	268 NX

Peritubular cells	122 NX
Testis	122 NX

Proximal tubular cells	194 NX
Kidney	194 NX

Rod photoreceptor cells	55 NX
Eye	55 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	222 NX
Prostate	241 NX
Pancreas	222 NX
Skin	197 NX
Heart muscle	93 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	14 NX
Testis	14 NX

Suprabasal keratinocytes	702 NX
Skin	702 NX

Syncytiotrophoblasts	323 NX
Placenta	323 NX

T-cells	77 NX
Skin	138 NX
Colon	131 NX
Kidney	101 NX
Prostate	92 NX
Liver	55 NX
Lung	10 NX

Undifferentiated cells	200 NX
Colon	417 NX
Rectum	200 NX
Small intestine	150 NX

Urothelial cells	332 NX
Prostate	332 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.