Cell type atlas - DDIT3 - The Human Protein Atlas

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DDIT3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDIT3
Gene descriptionⁱ Full gene name according to HGNC.	DNA damage inducible transcript 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HHSteC, hTERT-HME1, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	66 NX
Lung	66 NX

B-cells	37 NX
Colon	118 NX
Kidney	54 NX
Liver	17 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	50 NX
Skin	50 NX

Bipolar cells	111 NX
Eye	111 NX

Cardiomyocytes	146 NX
Heart muscle	146 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	86 NX
Eye	86 NX

Cytotrophoblasts	38 NX
Placenta	38 NX

Distal tubular cells	98 NX
Kidney	98 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	26 NX
Eye	102 NX
Skin	87 NX
Prostate	86 NX
Heart muscle	37 NX
Testis	26 NX
Placenta	22 NX
Pancreas	22 NX
Lung	20 NX
Liver	20 NX

Enterocytes	68 NX
Colon	502 NX
Small intestine	50 NX
Rectum	36 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	14 NX
Pancreas	14 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	64 NX
Prostate	196 NX
Heart muscle	96 NX
Lung	83 NX
Skin	65 NX
Placenta	32 NX

Glandular cells	157 NX
Prostate	157 NX

Granulocytes	199 NX
Colon	202 NX
Lung	195 NX

Hepatocytes	18 NX
Liver	18 NX

Hofbauer cells	40 NX
Placenta	40 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	221 NX
Colon	316 NX
Rectum	126 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	6 NX
Testis	5 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	51 NX
Prostate	161 NX
Lung	94 NX
Skin	69 NX
Pancreas	30 NX
Testis	26 NX
Kidney	24 NX

Melanocytes	84 NX
Skin	84 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	8 NX
Pancreas	8 NX

Mucus-secreting cells	37 NX
Colon	492 NX
Small intestine	45 NX
Rectum	27 NX

Muller glia cells	119 NX
Eye	119 NX

Pancreatic endocrine cells	36 NX
Pancreas	36 NX

Paneth cells	70 NX
Colon	694 NX
Small intestine	70 NX
Rectum	28 NX

Peritubular cells	36 NX
Testis	36 NX

Proximal tubular cells	35 NX
Kidney	35 NX

Rod photoreceptor cells	135 NX
Eye	135 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	94 NX
Skin	111 NX
Prostate	100 NX
Heart muscle	72 NX
Pancreas	33 NX

Spermatocytes	84 NX
Testis	84 NX

Spermatogonia	13 NX
Testis	13 NX

Suprabasal keratinocytes	40 NX
Skin	40 NX

Syncytiotrophoblasts	90 NX
Placenta	90 NX

T-cells	47 NX
Prostate	235 NX
Colon	109 NX
Lung	75 NX
Skin	59 NX
Kidney	34 NX
Liver	30 NX

Undifferentiated cells	32 NX
Colon	172 NX
Small intestine	32 NX
Rectum	21 NX

Urothelial cells	42 NX
Prostate	42 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.