Cell type atlas - MARCKSL1 - The Human Protein Atlas

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MARCKSL1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MARCKSL1
Gene descriptionⁱ Full gene name according to HGNC.	MARCKS like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (AF22, NTERA-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	2 NX
Lung	2 NX

B-cells	148 NX
Colon	242 NX
Kidney	169 NX
Liver	73 NX

Basal glandular cells	95 NX
Prostate	95 NX

Basal keratinocytes	83 NX
Skin	83 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	7 NX
Heart muscle	7 NX

Cholangiocytes	163 NX
Liver	163 NX

Ciliated cells	3 NX
Lung	3 NX

Club cells	5 NX
Lung	5 NX

Collecting duct cells	58 NX
Kidney	58 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	10 NX
Placenta	10 NX

Distal tubular cells	70 NX
Kidney	70 NX

Ductal cells	354 NX
Pancreas	354 NX

Early spermatids	22 NX
Testis	22 NX

Endothelial cells	182 NX
Pancreas	555 NX
Placenta	536 NX
Testis	308 NX
Prostate	299 NX
Skin	257 NX
Liver	178 NX
Eye	60 NX
Lung	44 NX
Heart muscle	23 NX

Enterocytes	54 NX
Rectum	183 NX
Colon	113 NX
Small intestine	24 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	269 NX
Pancreas	269 NX

Extravillous trophoblasts	99 NX
Placenta	99 NX

Fibroblasts	69 NX
Prostate	247 NX
Skin	84 NX
Placenta	55 NX
Heart muscle	40 NX
Lung	23 NX

Glandular cells	342 NX
Prostate	342 NX

Granulocytes	23 NX
Colon	46 NX
Lung	0 NX

Hepatocytes	4 NX
Liver	4 NX

Hofbauer cells	20 NX
Placenta	20 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	717 NX
Rectum	768 NX
Colon	666 NX

Ito cells	486 NX
Liver	486 NX

Kupffer cells	57 NX
Liver	57 NX

Late spermatids	36 NX
Testis	36 NX

Leydig cells	568 NX
Testis	568 NX

Macrophages	77 NX
Skin	218 NX
Kidney	86 NX
Prostate	85 NX
Pancreas	80 NX
Testis	12 NX
Lung	10 NX

Melanocytes	285 NX
Skin	285 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1596 NX
Pancreas	1596 NX

Mucus-secreting cells	443 NX
Rectum	532 NX
Colon	506 NX
Small intestine	344 NX

Muller glia cells	407 NX
Eye	407 NX

Pancreatic endocrine cells	518 NX
Pancreas	518 NX

Paneth cells	228 NX
Rectum	378 NX
Small intestine	228 NX
Colon	190 NX

Peritubular cells	603 NX
Testis	603 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	12 NX
Eye	12 NX

Sertoli cells	129 NX
Testis	129 NX

Smooth muscle cells	73 NX
Pancreas	186 NX
Prostate	73 NX
Skin	66 NX
Heart muscle	14 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	129 NX
Testis	129 NX

Suprabasal keratinocytes	73 NX
Skin	73 NX

Syncytiotrophoblasts	11 NX
Placenta	11 NX

T-cells	47 NX
Skin	102 NX
Prostate	100 NX
Colon	87 NX
Kidney	47 NX
Liver	21 NX
Lung	2 NX

Undifferentiated cells	387 NX
Rectum	391 NX
Colon	387 NX
Small intestine	293 NX

Urothelial cells	506 NX
Prostate	506 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.