Cell type atlas - TRMT10C - The Human Protein Atlas

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TRMT10C

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRMT10C
Gene descriptionⁱ Full gene name according to HGNC.	TRNA methyltransferase 10C, mitochondrial RNase P subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	45 NX
Kidney	67 NX
Colon	46 NX
Liver	43 NX

Basal glandular cells	115 NX
Prostate	115 NX

Basal keratinocytes	84 NX
Skin	84 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	45 NX
Heart muscle	45 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	44 NX
Lung	44 NX

Club cells	48 NX
Lung	48 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	57 NX
Placenta	57 NX

Distal tubular cells	45 NX
Kidney	45 NX

Ductal cells	45 NX
Pancreas	45 NX

Early spermatids	22 NX
Testis	22 NX

Endothelial cells	33 NX
Pancreas	61 NX
Prostate	55 NX
Placenta	41 NX
Lung	35 NX
Skin	33 NX
Testis	33 NX
Liver	27 NX
Heart muscle	26 NX
Eye	19 NX

Enterocytes	13 NX
Small intestine	17 NX
Rectum	10 NX
Colon	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	29 NX
Pancreas	29 NX

Extravillous trophoblasts	35 NX
Placenta	35 NX

Fibroblasts	35 NX
Prostate	53 NX
Lung	49 NX
Placenta	39 NX
Heart muscle	34 NX
Skin	33 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	46 NX
Colon	64 NX
Lung	28 NX

Hepatocytes	46 NX
Liver	46 NX

Hofbauer cells	28 NX
Placenta	28 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	34 NX
Colon	48 NX
Rectum	21 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	28 NX
Kidney	33 NX
Testis	31 NX
Lung	28 NX
Skin	28 NX
Pancreas	19 NX
Prostate	16 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	37 NX
Pancreas	37 NX

Mucus-secreting cells	27 NX
Colon	38 NX
Rectum	27 NX
Small intestine	20 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	32 NX
Pancreas	32 NX

Paneth cells	14 NX
Rectum	26 NX
Small intestine	14 NX
Colon	9 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	55 NX
Kidney	55 NX

Rod photoreceptor cells	29 NX
Eye	29 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	42 NX
Prostate	47 NX
Pancreas	44 NX
Heart muscle	36 NX
Skin	32 NX

Spermatocytes	61 NX
Testis	61 NX

Spermatogonia	51 NX
Testis	51 NX

Suprabasal keratinocytes	92 NX
Skin	92 NX

Syncytiotrophoblasts	55 NX
Placenta	55 NX

T-cells	42 NX
Prostate	83 NX
Colon	56 NX
Skin	44 NX
Lung	42 NX
Kidney	40 NX
Liver	28 NX

Undifferentiated cells	40 NX
Colon	59 NX
Small intestine	42 NX
Rectum	34 NX

Urothelial cells	115 NX
Prostate	115 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.