Cell type atlas - PLK3 - The Human Protein Atlas

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PLK3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLK3
Gene descriptionⁱ Full gene name according to HGNC.	Polo like kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	42 NX
Lung	42 NX

B-cells	19 NX
Colon	34 NX
Liver	19 NX
Kidney	5 NX

Basal glandular cells	52 NX
Prostate	52 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	5 NX
Eye	5 NX

Cardiomyocytes	2 NX
Heart muscle	2 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	9 NX
Lung	9 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	5 NX
Kidney	5 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	13 NX
Placenta	13 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	18 NX
Pancreas	18 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	30 NX
Eye	92 NX
Liver	47 NX
Prostate	41 NX
Placenta	37 NX
Skin	35 NX
Testis	30 NX
Pancreas	29 NX
Lung	18 NX
Heart muscle	17 NX

Enterocytes	74 NX
Colon	105 NX
Small intestine	38 NX
Rectum	29 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	11 NX
Pancreas	11 NX

Extravillous trophoblasts	19 NX
Placenta	19 NX

Fibroblasts	26 NX
Prostate	67 NX
Skin	35 NX
Lung	31 NX
Placenta	10 NX
Heart muscle	9 NX

Glandular cells	19 NX
Prostate	19 NX

Granulocytes	78 NX
Colon	110 NX
Lung	47 NX

Hepatocytes	5 NX
Liver	5 NX

Hofbauer cells	35 NX
Placenta	35 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	51 NX
Colon	78 NX
Rectum	23 NX

Ito cells	25 NX
Liver	25 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	9 NX
Testis	9 NX

Macrophages	53 NX
Prostate	167 NX
Testis	61 NX
Lung	53 NX
Pancreas	49 NX
Skin	46 NX
Kidney	16 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	11 NX
Pancreas	11 NX

Mucus-secreting cells	22 NX
Colon	95 NX
Small intestine	22 NX
Rectum	18 NX

Muller glia cells	5 NX
Eye	5 NX

Pancreatic endocrine cells	18 NX
Pancreas	18 NX

Paneth cells	67 NX
Colon	199 NX
Small intestine	67 NX
Rectum	47 NX

Peritubular cells	5 NX
Testis	5 NX

Proximal tubular cells	2 NX
Kidney	2 NX

Rod photoreceptor cells	10 NX
Eye	10 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	27 NX
Prostate	39 NX
Pancreas	34 NX
Skin	22 NX
Heart muscle	8 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	50 NX
Placenta	50 NX

T-cells	25 NX
Prostate	83 NX
Colon	74 NX
Skin	39 NX
Lung	25 NX
Kidney	24 NX
Liver	7 NX

Undifferentiated cells	28 NX
Colon	59 NX
Small intestine	31 NX
Rectum	25 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.