Cell type atlas - NUDT4 - The Human Protein Atlas

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NUDT4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUDT4
Gene descriptionⁱ Full gene name according to HGNC.	Nudix hydrolase 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Muller glia cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Muller glia cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	43 NX
Lung	43 NX

B-cells	41 NX
Colon	73 NX
Liver	34 NX
Kidney	27 NX

Basal glandular cells	111 NX
Prostate	111 NX

Basal keratinocytes	104 NX
Skin	104 NX

Bipolar cells	39 NX
Eye	39 NX

Cardiomyocytes	226 NX
Heart muscle	226 NX

Cholangiocytes	94 NX
Liver	94 NX

Ciliated cells	91 NX
Lung	91 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	59 NX
Eye	59 NX

Cytotrophoblasts	156 NX
Placenta	156 NX

Distal tubular cells	307 NX
Kidney	307 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	79 NX
Testis	79 NX

Endothelial cells	50 NX
Skin	207 NX
Prostate	109 NX
Lung	105 NX
Eye	73 NX
Heart muscle	50 NX
Liver	36 NX
Placenta	23 NX
Pancreas	22 NX
Testis	19 NX

Enterocytes	103 NX
Rectum	233 NX
Colon	141 NX
Small intestine	56 NX

Erythroid cells	327 NX
Liver	327 NX

Exocrine glandular cells	15 NX
Pancreas	15 NX

Extravillous trophoblasts	23 NX
Placenta	23 NX

Fibroblasts	86 NX
Skin	159 NX
Prostate	126 NX
Heart muscle	117 NX
Lung	48 NX
Placenta	25 NX

Glandular cells	143 NX
Prostate	143 NX

Granulocytes	25 NX
Colon	37 NX
Lung	14 NX

Hepatocytes	49 NX
Liver	49 NX

Hofbauer cells	38 NX
Placenta	38 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	146 NX
Colon	194 NX
Rectum	98 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	17 NX
Testis	17 NX

Leydig cells	36 NX
Testis	36 NX

Macrophages	32 NX
Prostate	64 NX
Skin	60 NX
Lung	32 NX
Testis	26 NX
Kidney	26 NX
Pancreas	16 NX

Melanocytes	101 NX
Skin	101 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	13 NX
Pancreas	13 NX

Mucus-secreting cells	84 NX
Colon	97 NX
Rectum	84 NX
Small intestine	43 NX

Muller glia cells	412 NX
Eye	412 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	86 NX
Colon	118 NX
Rectum	86 NX
Small intestine	46 NX

Peritubular cells	44 NX
Testis	44 NX

Proximal tubular cells	43 NX
Kidney	43 NX

Rod photoreceptor cells	40 NX
Eye	40 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	167 NX
Prostate	371 NX
Skin	259 NX
Heart muscle	148 NX
Pancreas	27 NX

Spermatocytes	29 NX
Testis	29 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	85 NX
Skin	85 NX

Syncytiotrophoblasts	137 NX
Placenta	137 NX

T-cells	30 NX
Prostate	196 NX
Colon	126 NX
Skin	102 NX
Liver	29 NX
Kidney	29 NX
Lung	20 NX

Undifferentiated cells	64 NX
Colon	106 NX
Rectum	75 NX
Small intestine	43 NX

Urothelial cells	134 NX
Prostate	134 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.