Cell type atlas - PPP1R14B - The Human Protein Atlas

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PPP1R14B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP1R14B
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 1 regulatory inhibitor subunit 14B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	40 NX
Liver	51 NX
Kidney	40 NX
Colon	40 NX

Basal glandular cells	71 NX
Prostate	71 NX

Basal keratinocytes	203 NX
Skin	203 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	33 NX
Heart muscle	33 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	5 NX
Lung	5 NX

Club cells	10 NX
Lung	10 NX

Collecting duct cells	75 NX
Kidney	75 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	52 NX
Placenta	52 NX

Distal tubular cells	65 NX
Kidney	65 NX

Ductal cells	115 NX
Pancreas	115 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	45 NX
Prostate	206 NX
Skin	121 NX
Pancreas	54 NX
Placenta	53 NX
Liver	45 NX
Eye	44 NX
Testis	16 NX
Heart muscle	11 NX
Lung	9 NX

Enterocytes	68 NX
Small intestine	98 NX
Colon	57 NX
Rectum	48 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	200 NX
Pancreas	200 NX

Extravillous trophoblasts	508 NX
Placenta	508 NX

Fibroblasts	40 NX
Skin	81 NX
Prostate	75 NX
Placenta	35 NX
Heart muscle	19 NX
Lung	11 NX

Glandular cells	108 NX
Prostate	108 NX

Granulocytes	28 NX
Colon	46 NX
Lung	9 NX

Hepatocytes	90 NX
Liver	90 NX

Hofbauer cells	82 NX
Placenta	82 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	80 NX
Colon	105 NX
Rectum	54 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	9 NX
Testis	9 NX

Macrophages	37 NX
Pancreas	103 NX
Prostate	91 NX
Skin	76 NX
Kidney	37 NX
Testis	22 NX
Lung	17 NX

Melanocytes	57 NX
Skin	57 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	106 NX
Pancreas	106 NX

Mucus-secreting cells	77 NX
Colon	157 NX
Rectum	67 NX
Small intestine	54 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	225 NX
Pancreas	225 NX

Paneth cells	43 NX
Rectum	60 NX
Colon	43 NX
Small intestine	35 NX

Peritubular cells	11 NX
Testis	11 NX

Proximal tubular cells	48 NX
Kidney	48 NX

Rod photoreceptor cells	18 NX
Eye	18 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	43 NX
Pancreas	138 NX
Prostate	54 NX
Skin	41 NX
Heart muscle	24 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	13 NX
Testis	13 NX

Suprabasal keratinocytes	226 NX
Skin	226 NX

Syncytiotrophoblasts	111 NX
Placenta	111 NX

T-cells	20 NX
Skin	42 NX
Colon	28 NX
Kidney	23 NX
Lung	22 NX
Prostate	18 NX
Liver	12 NX

Undifferentiated cells	88 NX
Colon	117 NX
Rectum	89 NX
Small intestine	76 NX

Urothelial cells	174 NX
Prostate	174 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.