Cell type atlas - PARP14 - The Human Protein Atlas

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PARP14

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PARP14
Gene descriptionⁱ Full gene name according to HGNC.	Poly(ADP-ribose) polymerase family member 14
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	229 NX
Lung	229 NX

Alveolar cells type 2	87 NX
Lung	87 NX

B-cells	41 NX
Colon	143 NX
Kidney	40 NX
Liver	25 NX

Basal glandular cells	15 NX
Prostate	15 NX

Basal keratinocytes	15 NX
Skin	15 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	52 NX
Lung	52 NX

Club cells	84 NX
Lung	84 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	12 NX
Placenta	12 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	62 NX
Lung	166 NX
Heart muscle	165 NX
Prostate	81 NX
Eye	70 NX
Testis	54 NX
Skin	49 NX
Pancreas	47 NX
Liver	38 NX
Placenta	26 NX

Enterocytes	21 NX
Small intestine	24 NX
Rectum	23 NX
Colon	12 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	36 NX
Pancreas	36 NX

Extravillous trophoblasts	24 NX
Placenta	24 NX

Fibroblasts	20 NX
Lung	52 NX
Heart muscle	40 NX
Prostate	34 NX
Skin	23 NX
Placenta	16 NX

Glandular cells	24 NX
Prostate	24 NX

Granulocytes	30 NX
Lung	51 NX
Colon	9 NX

Hepatocytes	30 NX
Liver	30 NX

Hofbauer cells	32 NX
Placenta	32 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	10 NX
Colon	14 NX
Rectum	7 NX

Ito cells	68 NX
Liver	68 NX

Kupffer cells	51 NX
Liver	51 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	51 NX
Lung	150 NX
Testis	66 NX
Kidney	59 NX
Pancreas	42 NX
Prostate	42 NX
Skin	38 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	95 NX
Pancreas	95 NX

Mucus-secreting cells	14 NX
Small intestine	27 NX
Colon	13 NX
Rectum	9 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	34 NX
Pancreas	34 NX

Paneth cells	18 NX
Colon	26 NX
Small intestine	18 NX
Rectum	11 NX

Peritubular cells	16 NX
Testis	16 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	18 NX
Heart muscle	64 NX
Prostate	18 NX
Skin	17 NX
Pancreas	7 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	4 NX
Placenta	4 NX

T-cells	27 NX
Lung	115 NX
Colon	43 NX
Liver	28 NX
Kidney	27 NX
Prostate	26 NX
Skin	25 NX

Undifferentiated cells	11 NX
Small intestine	15 NX
Rectum	10 NX
Colon	10 NX

Urothelial cells	21 NX
Prostate	21 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.