Cell type atlas - ESRRA - The Human Protein Atlas

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ESRRA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ESRRA
Gene descriptionⁱ Full gene name according to HGNC.	Estrogen related receptor alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Nuclear receptors Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	30 NX
Liver	64 NX
Kidney	18 NX
Colon	15 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	29 NX
Eye	29 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	133 NX
Liver	133 NX

Ciliated cells	5 NX
Lung	5 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	80 NX
Placenta	80 NX

Distal tubular cells	46 NX
Kidney	46 NX

Ductal cells	50 NX
Pancreas	50 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	9 NX
Liver	45 NX
Pancreas	22 NX
Prostate	20 NX
Placenta	17 NX
Eye	14 NX
Testis	9 NX
Lung	9 NX
Skin	8 NX
Heart muscle	1 NX

Enterocytes	144 NX
Small intestine	176 NX
Rectum	162 NX
Colon	106 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	69 NX
Pancreas	69 NX

Extravillous trophoblasts	49 NX
Placenta	49 NX

Fibroblasts	12 NX
Prostate	15 NX
Placenta	13 NX
Skin	12 NX
Lung	5 NX
Heart muscle	3 NX

Glandular cells	19 NX
Prostate	19 NX

Granulocytes	7 NX
Lung	14 NX
Colon	0 NX

Hepatocytes	155 NX
Liver	155 NX

Hofbauer cells	30 NX
Placenta	30 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	36 NX
Rectum	42 NX
Colon	31 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	94 NX
Liver	94 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	6 NX
Testis	6 NX

Macrophages	20 NX
Prostate	33 NX
Kidney	29 NX
Pancreas	23 NX
Lung	20 NX
Testis	12 NX
Skin	10 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	20 NX
Pancreas	20 NX

Mucus-secreting cells	72 NX
Rectum	77 NX
Small intestine	71 NX
Colon	66 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	67 NX
Pancreas	67 NX

Paneth cells	95 NX
Colon	95 NX
Small intestine	95 NX
Rectum	90 NX

Peritubular cells	11 NX
Testis	11 NX

Proximal tubular cells	48 NX
Kidney	48 NX

Rod photoreceptor cells	19 NX
Eye	19 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	10 NX
Pancreas	29 NX
Prostate	22 NX
Skin	10 NX
Heart muscle	2 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	16 NX
Skin	16 NX

Syncytiotrophoblasts	112 NX
Placenta	112 NX

T-cells	15 NX
Liver	28 NX
Prostate	26 NX
Colon	15 NX
Lung	14 NX
Kidney	14 NX
Skin	10 NX

Undifferentiated cells	83 NX
Rectum	101 NX
Small intestine	83 NX
Colon	67 NX

Urothelial cells	50 NX
Prostate	50 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.