Cell type atlas - CORO1B - The Human Protein Atlas

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CORO1B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CORO1B
Gene descriptionⁱ Full gene name according to HGNC.	Coronin 1B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, Paneth cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, Paneth cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	2 NX
Lung	2 NX

B-cells	39 NX
Kidney	71 NX
Colon	48 NX
Liver	29 NX

Basal glandular cells	51 NX
Prostate	51 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	11 NX
Eye	11 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	0 NX
Lung	0 NX

Club cells	3 NX
Lung	3 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	81 NX
Placenta	81 NX

Distal tubular cells	51 NX
Kidney	51 NX

Ductal cells	101 NX
Pancreas	101 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	45 NX
Pancreas	82 NX
Testis	74 NX
Placenta	73 NX
Eye	56 NX
Prostate	45 NX
Skin	41 NX
Liver	36 NX
Heart muscle	1 NX
Lung	0 NX

Enterocytes	241 NX
Colon	379 NX
Rectum	202 NX
Small intestine	198 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	92 NX
Pancreas	92 NX

Extravillous trophoblasts	190 NX
Placenta	190 NX

Fibroblasts	40 NX
Placenta	53 NX
Skin	39 NX
Prostate	32 NX
Heart muscle	1 NX
Lung	0 NX

Glandular cells	58 NX
Prostate	58 NX

Granulocytes	29 NX
Colon	55 NX
Lung	2 NX

Hepatocytes	20 NX
Liver	20 NX

Hofbauer cells	220 NX
Placenta	220 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	95 NX
Colon	129 NX
Rectum	61 NX

Ito cells	42 NX
Liver	42 NX

Kupffer cells	90 NX
Liver	90 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	37 NX
Testis	37 NX

Macrophages	75 NX
Pancreas	187 NX
Prostate	111 NX
Kidney	94 NX
Testis	77 NX
Skin	65 NX
Lung	2 NX

Melanocytes	67 NX
Skin	67 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	281 NX
Pancreas	281 NX

Mucus-secreting cells	138 NX
Colon	224 NX
Small intestine	188 NX
Rectum	107 NX

Muller glia cells	26 NX
Eye	26 NX

Pancreatic endocrine cells	112 NX
Pancreas	112 NX

Paneth cells	281 NX
Colon	464 NX
Small intestine	281 NX
Rectum	130 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	63 NX
Kidney	63 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	45 NX
Pancreas	72 NX
Skin	52 NX
Prostate	45 NX
Heart muscle	2 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	27 NX
Skin	27 NX

Syncytiotrophoblasts	126 NX
Placenta	126 NX

T-cells	77 NX
Skin	168 NX
Kidney	149 NX
Lung	92 NX
Colon	92 NX
Prostate	39 NX
Liver	29 NX

Undifferentiated cells	99 NX
Colon	147 NX
Small intestine	95 NX
Rectum	91 NX

Urothelial cells	63 NX
Prostate	63 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.