Cell type atlas - GNB2 - The Human Protein Atlas

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GNB2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNB2
Gene descriptionⁱ Full gene name according to HGNC.	G protein subunit beta 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	113 NX
Lung	113 NX

B-cells	84 NX
Colon	91 NX
Kidney	89 NX
Liver	74 NX

Basal glandular cells	122 NX
Prostate	122 NX

Basal keratinocytes	135 NX
Skin	135 NX

Bipolar cells	7 NX
Eye	7 NX

Cardiomyocytes	30 NX
Heart muscle	30 NX

Cholangiocytes	107 NX
Liver	107 NX

Ciliated cells	38 NX
Lung	38 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	80 NX
Kidney	80 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	159 NX
Placenta	159 NX

Distal tubular cells	138 NX
Kidney	138 NX

Ductal cells	145 NX
Pancreas	145 NX

Early spermatids	23 NX
Testis	23 NX

Endothelial cells	125 NX
Prostate	169 NX
Placenta	156 NX
Skin	151 NX
Liver	126 NX
Pancreas	125 NX
Eye	118 NX
Testis	109 NX
Heart muscle	43 NX
Lung	29 NX

Enterocytes	215 NX
Colon	278 NX
Rectum	236 NX
Small intestine	127 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	189 NX
Pancreas	189 NX

Extravillous trophoblasts	251 NX
Placenta	251 NX

Fibroblasts	125 NX
Placenta	139 NX
Skin	129 NX
Prostate	106 NX
Lung	37 NX
Heart muscle	31 NX

Glandular cells	201 NX
Prostate	201 NX

Granulocytes	44 NX
Colon	55 NX
Lung	33 NX

Hepatocytes	59 NX
Liver	59 NX

Hofbauer cells	231 NX
Placenta	231 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	173 NX
Colon	173 NX
Rectum	173 NX

Ito cells	118 NX
Liver	118 NX

Kupffer cells	164 NX
Liver	164 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	134 NX
Testis	134 NX

Macrophages	187 NX
Pancreas	204 NX
Kidney	204 NX
Testis	193 NX
Prostate	192 NX
Skin	167 NX
Lung	94 NX

Melanocytes	133 NX
Skin	133 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	162 NX
Pancreas	162 NX

Mucus-secreting cells	168 NX
Colon	235 NX
Rectum	166 NX
Small intestine	148 NX

Muller glia cells	120 NX
Eye	120 NX

Pancreatic endocrine cells	203 NX
Pancreas	203 NX

Paneth cells	197 NX
Colon	394 NX
Rectum	197 NX
Small intestine	175 NX

Peritubular cells	122 NX
Testis	122 NX

Proximal tubular cells	84 NX
Kidney	84 NX

Rod photoreceptor cells	7 NX
Eye	7 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	123 NX
Pancreas	219 NX
Prostate	191 NX
Skin	113 NX
Heart muscle	27 NX

Spermatocytes	36 NX
Testis	36 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	170 NX
Skin	170 NX

Syncytiotrophoblasts	246 NX
Placenta	246 NX

T-cells	92 NX
Kidney	111 NX
Skin	110 NX
Liver	99 NX
Colon	87 NX
Prostate	65 NX
Lung	29 NX

Undifferentiated cells	153 NX
Colon	216 NX
Rectum	163 NX
Small intestine	132 NX

Urothelial cells	221 NX
Prostate	221 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.