Cell type atlas - BSG - The Human Protein Atlas

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BSG

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BSG
Gene descriptionⁱ Full gene name according to HGNC.	Basigin (Ok blood group)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Blood group antigen proteins CD markers Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	97 NX
Liver	139 NX
Colon	105 NX
Kidney	89 NX

Basal glandular cells	148 NX
Prostate	148 NX

Basal keratinocytes	185 NX
Skin	185 NX

Bipolar cells	142 NX
Eye	142 NX

Cardiomyocytes	74 NX
Heart muscle	74 NX

Cholangiocytes	104 NX
Liver	104 NX

Ciliated cells	62 NX
Lung	62 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	272 NX
Kidney	272 NX

Cone photoreceptor cells	192 NX
Eye	192 NX

Cytotrophoblasts	1239 NX
Placenta	1239 NX

Distal tubular cells	124 NX
Kidney	124 NX

Ductal cells	507 NX
Pancreas	507 NX

Early spermatids	197 NX
Testis	197 NX

Endothelial cells	200 NX
Eye	605 NX
Placenta	416 NX
Pancreas	304 NX
Testis	210 NX
Liver	200 NX
Skin	188 NX
Prostate	146 NX
Heart muscle	25 NX
Lung	23 NX

Enterocytes	715 NX
Colon	1006 NX
Rectum	852 NX
Small intestine	376 NX

Erythroid cells	607 NX
Liver	607 NX

Exocrine glandular cells	327 NX
Pancreas	327 NX

Extravillous trophoblasts	910 NX
Placenta	910 NX

Fibroblasts	250 NX
Placenta	827 NX
Prostate	240 NX
Skin	237 NX
Lung	78 NX
Heart muscle	41 NX

Glandular cells	170 NX
Prostate	170 NX

Granulocytes	116 NX
Colon	175 NX
Lung	58 NX

Hepatocytes	85 NX
Liver	85 NX

Hofbauer cells	379 NX
Placenta	379 NX

Horizontal cells	132 NX
Eye	132 NX

Intestinal endocrine cells	245 NX
Colon	258 NX
Rectum	232 NX

Ito cells	132 NX
Liver	132 NX

Kupffer cells	136 NX
Liver	136 NX

Late spermatids	474 NX
Testis	474 NX

Leydig cells	278 NX
Testis	278 NX

Macrophages	146 NX
Pancreas	339 NX
Kidney	186 NX
Skin	168 NX
Prostate	133 NX
Testis	109 NX
Lung	56 NX

Melanocytes	481 NX
Skin	481 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	346 NX
Pancreas	346 NX

Mucus-secreting cells	224 NX
Colon	464 NX
Rectum	224 NX
Small intestine	204 NX

Muller glia cells	452 NX
Eye	452 NX

Pancreatic endocrine cells	370 NX
Pancreas	369 NX

Paneth cells	481 NX
Colon	1644 NX
Rectum	481 NX
Small intestine	351 NX

Peritubular cells	316 NX
Testis	316 NX

Proximal tubular cells	241 NX
Kidney	241 NX

Rod photoreceptor cells	168 NX
Eye	168 NX

Sertoli cells	201 NX
Testis	201 NX

Smooth muscle cells	269 NX
Pancreas	382 NX
Prostate	269 NX
Skin	244 NX
Heart muscle	22 NX

Spermatocytes	259 NX
Testis	259 NX

Spermatogonia	554 NX
Testis	554 NX

Suprabasal keratinocytes	137 NX
Skin	137 NX

Syncytiotrophoblasts	1384 NX
Placenta	1384 NX

T-cells	132 NX
Kidney	198 NX
Colon	185 NX
Skin	157 NX
Liver	123 NX
Prostate	113 NX
Lung	27 NX

Undifferentiated cells	329 NX
Colon	493 NX
Small intestine	322 NX
Rectum	304 NX

Urothelial cells	156 NX
Prostate	156 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.