CLEC7A protein expression summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

Search result

Field

Pathway

HELP

NEWS

CLEC7A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	C-type lectin domain containing 7A
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLEC7A (CD369, CLECSF12, dectin-1, hDectin-1, SCARE2)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Group enriched (blood, bone marrow, brain, lung, lymphoid tissue)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Kupffer cells, Macrophages, Hofbauer cells)
Blood specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low human brain regional specificity
Cancer prognostic summary	Prognostic marker in renal cancer (unfavorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular, Membrane (different isoforms)
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Receptor
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Immunity, Inflammatory response, Innate immunity
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	Lectin, Metal-binding
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]... show less

TISSUE ATLASⁱ Summary of data presented in the Tissue Atlas and representative images of protein expression (left) and mRNA expression (right). The images are clickable and will redirect to more Tissue Atlas data. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Group enriched (blood, bone marrow, brain, lung, lymphoid tissue)
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many

SINGLE CELL TYPE ATLASⁱ Summary of data presented in the Cell Type Atlas and an interactive image showing mRNA expression in cell type groups e.g. epithelial cells and germ cells. The image is clickable and will redirect to more Cell Type Atlas data. The Cell Type Atlas contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Kupffer cells, Macrophages, Hofbauer cells)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (Karpas-707, U-266/84)

PATHOLOGY ATLASⁱ Summary of data presented in the Pathology Atlas , with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology Atlas data. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
Renal cancer p<0.001
Prognostic summary	Prognostic marker in renal cancer (unfavorable)
Cancer specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

BRAIN ATLASⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

BLOOD ATLASⁱ Summary of data presented in the Blood Atlas and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more Blood Atlas data. The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e.g. B-cells and granulocytes. Analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) and proteins detected in human blood are also presented. Read more

Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No

CELL ATLASⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Not available
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data. Read more	NA

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CLEC7A (HGNC Symbol)
Synonyms	CD369, CLECSF12, dectin-1, hDectin-1, SCARE2
Description	C-type lectin domain containing 7A (HGNC Symbol)
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10116777 - 10130258
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Ensembl	ENSG00000172243 (version 92.38)
Entrez gene	64581
UniProt	Q9BXN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXN2
Antibodypedia	CLEC7A antibodies

PROTEIN BROWSERⁱ

CLEC7A-201

CLEC7A-202

CLEC7A-203

CLEC7A-205

CLEC7A-206

CLEC7A-208

CLEC7A-212

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC7A-201 ENSP00000298523 ENST00000298523	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	143 aa 16 kDa	No	1
CLEC7A-202 ENSP00000302569 ENST00000304084	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A A0A024RAN9 [Target identity:100%; Query identity:100%] C-type lectin domain family 7, member A, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	247 aa 27.6 kDa	No	1
CLEC7A-203 ENSP00000312089 ENST00000310002	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A A0A0S2Z5Q1 [Target identity:100%; Query identity:100%] C-type lectin domain family 7 member A isoform 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	77 aa 8.4 kDa	No	1
CLEC7A-205 ENSP00000266456 ENST00000353231	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	201 aa 22.6 kDa	No	1
CLEC7A-206 ENSP00000379743 ENST00000396484	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	168 aa 19.2 kDa	No	0
CLEC7A-208 ENSP00000434954 ENST00000525605	Q68D78 [Direct mapping] C-type lectin domain family 7 member A; C-type lectin domain family 7 member A isoform 2; Uncharacterized protein DKFZp686L24211; cDNA FLJ59887, moderately similar to Homo sapiens C-type lectin domain family 7, member A (CLEC7A), transcript variant 4, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	136 aa 15.6 kDa	No	2
CLEC7A-212 ENSP00000431461 ENST00000533022	Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006910 [phagocytosis, recognition] GO:0006954 [inflammatory response] GO:0008037 [cell recognition] GO:0008329 [signaling pattern recognition receptor activity] GO:0009756 [carbohydrate mediated signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0042110 [T cell activation] GO:0042287 [MHC protein binding] GO:0042832 [defense response to protozoan] GO:0043231 [intracellular membrane-bounded organelle] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	189 aa 21.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.