Cell type atlas - QARS - The Human Protein Atlas

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QARS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	QARS
Gene descriptionⁱ Full gene name according to HGNC.	Glutaminyl-tRNA synthetase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	57 NX
Lung	57 NX

B-cells	56 NX
Colon	78 NX
Liver	45 NX
Kidney	36 NX

Basal glandular cells	52 NX
Prostate	52 NX

Basal keratinocytes	60 NX
Skin	60 NX

Bipolar cells	10 NX
Eye	10 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	23 NX
Lung	23 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	161 NX
Placenta	161 NX

Distal tubular cells	58 NX
Kidney	58 NX

Ductal cells	68 NX
Pancreas	67 NX

Early spermatids	150 NX
Testis	150 NX

Endothelial cells	50 NX
Placenta	74 NX
Testis	54 NX
Skin	52 NX
Liver	52 NX
Pancreas	50 NX
Heart muscle	47 NX
Lung	32 NX
Prostate	32 NX
Eye	29 NX

Enterocytes	110 NX
Small intestine	115 NX
Colon	110 NX
Rectum	83 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	95 NX
Pancreas	95 NX

Extravillous trophoblasts	128 NX
Placenta	128 NX

Fibroblasts	48 NX
Placenta	96 NX
Skin	46 NX
Heart muscle	22 NX
Lung	21 NX
Prostate	19 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	38 NX
Colon	46 NX
Lung	30 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	86 NX
Placenta	86 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	62 NX
Rectum	70 NX
Colon	54 NX

Ito cells	50 NX
Liver	50 NX

Kupffer cells	99 NX
Liver	99 NX

Late spermatids	438 NX
Testis	438 NX

Leydig cells	54 NX
Testis	54 NX

Macrophages	55 NX
Skin	59 NX
Testis	57 NX
Pancreas	56 NX
Prostate	54 NX
Kidney	54 NX
Lung	50 NX

Melanocytes	46 NX
Skin	46 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	120 NX
Pancreas	120 NX

Mucus-secreting cells	127 NX
Colon	155 NX
Rectum	141 NX
Small intestine	88 NX

Muller glia cells	21 NX
Eye	21 NX

Pancreatic endocrine cells	67 NX
Pancreas	67 NX

Paneth cells	72 NX
Rectum	134 NX
Colon	72 NX
Small intestine	63 NX

Peritubular cells	34 NX
Testis	34 NX

Proximal tubular cells	63 NX
Kidney	63 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	43 NX
Pancreas	60 NX
Skin	47 NX
Prostate	29 NX
Heart muscle	26 NX

Spermatocytes	18 NX
Testis	18 NX

Spermatogonia	47 NX
Testis	47 NX

Suprabasal keratinocytes	75 NX
Skin	75 NX

Syncytiotrophoblasts	156 NX
Placenta	156 NX

T-cells	69 NX
Liver	82 NX
Colon	79 NX
Lung	50 NX
Kidney	47 NX
Skin	45 NX
Prostate	18 NX

Undifferentiated cells	177 NX
Colon	189 NX
Rectum	168 NX
Small intestine	160 NX

Urothelial cells	57 NX
Prostate	57 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.